Evidence map›Paper›PMID 31948429›Full record

ArticleBMC women's health2020

Evaluating DREAMS HIV prevention interventions targeting adolescent girls and young women in high HIV prevalence districts in South Africa: protocol for a cross-sectional study.

Gavin George, Cherie Cawood, Adrian Puren, David Khanyile, Annette Gerritsen, Kaymarlin Govender, Sean Beckett, Mary Glenshaw, Karidia Diallo, Kassahun Ayalew and 5 more

Open access · goldAbstract read
In one paragraph

Article in BMC women's health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Gavin GeorgeHealth Economics and HIV and AIDS Research Division (HEARD), 4th Floor, J Block, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
Cherie CawoodEpicentre AIDs Risk Management (Pty) Limited, Paarl, South Africa.
Adrian PurenCentre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service (NICD/NHLS), Johannesburg, South Africa.
David KhanyileEpicentre AIDs Risk Management (Pty) Limited, Paarl, South Africa.
Annette GerritsenEpicentre AIDs Risk Management (Pty) Limited, Paarl, South Africa.
Kaymarlin GovenderHealth Economics and HIV and AIDS Research Division (HEARD), 4th Floor, J Block, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
Sean BeckettHealth Economics and HIV and AIDS Research Division (HEARD), 4th Floor, J Block, Westville Campus, University of KwaZulu-Natal, Durban, South Africa. becketts@ukzn.ac.za.ORCID 0000-0002-6207-3454
Mary GlenshawU.S. Centers for Disease Control and Prevention (CDC), Pretoria, South Africa.
Karidia DialloU.S. Centers for Disease Control and Prevention (CDC), Pretoria, South Africa.
Kassahun AyalewU.S. Centers for Disease Control and Prevention (CDC), Pretoria, South Africa.
Andrew GibbsHealth Economics and HIV and AIDS Research Division (HEARD), 4th Floor, J Block, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
Tarylee ReddyBiostatistics Research Unit, South African Medical Research Council (SAMRC), Durban, South Africa.
Lorna MaduraiGlobal Clinical and Virology Laboratory, Amanzimtoti, Durban, South Africa.
Tendesayi Kufa-ChakezhaCentre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service (NICD/NHLS), Johannesburg, South Africa.
Ayesha B M KharsanyCentre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
Epicentre (South Africa) · ZAUniversity of KwaZulu-Natal · ZANational Health Laboratory Service · ZASouth African Medical Research Council · ZACentre for the AIDS Programme of Research in South Africa · ZA

Funding

CDC HHS U2GGH000372CGH CDC HHS U2G GH000372PEPFAR
6 · The paper itself

Abstract

backgroundYoung women in sub-Saharan Africa remain at the epicentre of the HIV epidemic, with surveillance data indicating persistent high levels of HIV incidence. In South Africa, adolescent girls and young women (AGYW) account for a quarter of all new HIV infections. Determined, Resilient, Empowered, AIDS-free, Mentored and Safe (DREAMS) is a strategy introduced by the United States President's Emergency Plan for AIDS Relief (PEPFAR) aimed at reducing HIV incidence among AGYW in 10 countries in sub-Saharan Africa by 25% in the programme's first year, and by 40% in the second year. This study will assess the change in HIV incidence and reduction in risk associated behaviours that can be attributed to the DREAMS initiative in South Africa, using a population-based cross-sectional survey.

methodsData will be collected from a household-based representative sample of AGYW (between the ages 12-24 years) in four high prevalence districts (more than 10% of the population have HIV in these districts) in South Africa in which DREAMS has been implemented. A stratified cluster-based sampling approach will be used to select eligible participants for a cross-sectional survey with 18,500, to be conducted over 2017/2018. A questionnaire will be administered containing questions on sexual risk behaviour, selected academic and developmental milestones, prevalence of gender based violence, whilst examining exposure to DREAMS programmes. Biological samples, including two micro-containers of blood and self-collected vulvovaginal swab samples, are collected in each survey to test for HIV infection, HIV incidence, sexually transmitted infections (STIs) and pregnancy. This study will measure trends in population level HIV incidence using the Limiting antigen (LAg) Avidity Enzyme Immuno-Assay (EIA) and monitor changes in HIV incidence. DISCUSSION: Ending the HIV/AIDS pandemic by 2030 requires the continual monitoring and evaluation of prevention programmes, with the aim of optimising efforts and ensuring the achievement of epidemic control. This study will determine the impact DREAMS interventions have had on HIV incidence among AGYW in a 'real world, non-trial setting'.

Indexed as

HIV InfectionsPreventive Health ServicesRisk Reduction BehaviorSexual BehaviorAdolescentCross-Sectional StudiesFemaleHumansIncidenceLongitudinal StudiesPrevalenceSouth AfricaYoung AdultAdolescent healthAGYWDREAMSHIV incidenceHIV preventionSouth Africa

Identifiers

PMID31948429
PMCPMC6966796
OpenAlexW3004867655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.