Trial reportBMC neurology2020
A new approach to characterize postural deficits in chemotherapy-induced peripheral neuropathy and to analyze postural adaptions after an exercise intervention.
Trial report in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Effectiveness of Sensorimotor and Balance Training Compared to Conventional Physiotherapy on Balance and Quality of Life in Chemotherapy-Induced Peripheral Neuropathy: A Randomised Controlled Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Trial
- Type of exercise may influence postural adaptations in chemotherapy-induced peripheral neuropathy.Annals of clinical and translational neurology · 2021Trial
- Effect of tango versus exercise on chemotherapy-induced neuropathy after breast cancer treatment: a Phase II randomized controlled trial.Research square · 2026Article
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- Assessment of balance control mechanisms in patient populations using perturbation-based modeling: a narrative review with clinical implications.Frontiers in human neuroscience · 2026Review
- Slowing down in PNP: relationship of joint velocities in an arm-movement test and the fast TUG test.Scientific reports · 2025Article
- Postural control impairments following neurotoxic chemotherapy in women with cancer: a prospective observational study.BMC women's health · 2025Observational
- Head posture control under perturbed conditions in progressive supranuclear palsy patients.Frontiers in systems neuroscience · 2025Article
- Applications of Robotic Exoskeletons as Motion-Assistive Systems in Cancer Rehabilitation.Research (Washington, D.C.) · 2025Review
- Chemotherapy-Induced Peripheral Neuropathy and Falls in Cancer Survivors Relate to Digital Balance and Gait Impairments.JCO precision oncology · 2024Article
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- Article
- Article
- "PNP slows down" - linearly-reduced whole body joint velocities and altered gait patterns in polyneuropathy.Frontiers in human neuroscience · 2023Article
- Cancer survivors post-chemotherapy exhibit unique proprioceptive deficits in proximal limbs.Journal of neuroengineering and rehabilitation · 2022Article
- Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control.Scientific reports · 2021Article
- A review of movement disorders in chemotherapy-induced neurotoxicity.Journal of neuroengineering and rehabilitation · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostural instability presents a common and disabling consequence of chemotherapy-induced peripheral neuropathy (CIPN). However, knowledge about postural behavior of CIPN patients is sparse. With this pilot study, we used a new approach to i) characterize postural impairments as compared to healthy subjects, ii) allocate possible abnormalities to a set of parameters describing sensorimotor function, and iii) evaluate the effects of a balance-based exercise intervention.
methodsWe analyzed spontaneous and externally perturbed postural control in eight CIPN patients before and after a balance-based exercise intervention by using a modification of an established postural control model. These findings were compared to 15 matched healthy subjects.
resultsSpontaneous sway amplitude and velocity were larger in CIPN patients compared to healthy subjects. CIPN patients' reactions to external perturbations were smaller compared to healthy subjects, indicating that patients favor vestibular over proprioceptive sensory information. The balance-based exercise intervention up-weighted proprioceptive information in patients.
conclusionsCIPN patients' major postural deficit may relate to underuse of proprioceptive information that results in a less accurate posture control as spontaneous sway results indicate. The balance-based exercise intervention is able to partially correct for this abnormality. Our study contributes to a better understanding of postural impairments in CIPN patients and suggests an effective treatment strategy.
trial registrationGerman Clinical Trials Register: DRKS00004340, retrospectively registered 04 January 2013.
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