Evidence map›Paper›PMID 31948053›Full record

ArticleInternational journal of molecular sciences2020

The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.

Philipp Mayer, Alica Linnebacher, Hannah Glennemeier-Marke, Nicole Marnet, Frank Bergmann, Thilo Hackert, Miriam Klauss, Tanja Poth, Matthias M Gaida

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025
    Review
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  6. Comparison of early and lateScientific reports · 2023
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  13. Basic and Translational Models of Cooperative Oncogenesis.International journal of molecular sciences · 2020
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Philipp MayerClinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Alica LinnebacherInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Hannah Glennemeier-MarkeInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Nicole MarnetInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Frank BergmannInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Thilo HackertDepartment of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Miriam KlaussClinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Tanja PothInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Matthias M GaidaInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Heidelberg University · DEJohannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft GA1818/2-1
6 · The paper itself

Abstract

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a diagnostic tool that is increasingly used for the detection and characterization of focal masses in the abdomen, among these, pancreatic ductal adenocarcinoma (PDAC). DW-MRI reflects the microarchitecture of the tissue, and changes in diffusion, which are reflected by changes in the apparent diffusion coefficient (ADC), are mainly attributed to variations in cellular density, glandular formation, and fibrosis. When analyzing the T cell infiltrates, we found an association of a tumor-promoting subpopulation, characterized by the expression of interleukin (IL) 21 and IL26, with high ADC values. Moreover, the presence of IL21

Indexed as

Diffusion Magnetic Resonance ImagingAgedCarcinoma, Pancreatic DuctalCD3 ComplexCell Line, TumorFemaleHumansImmunohistochemistryInterleukin-10 Receptor beta SubunitInterleukin-21InterleukinsMaleMiddle AgedMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Pancreatic NeoplasmsCD3 ComplexIL10RB protein, humanIL26 protein, humanInterleukin-10 Receptor beta Subunitinterleukin-20 receptorInterleukin-21InterleukinsMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptors, InterleukinSTAT3 protein, humanSTAT3 Transcription FactorADCDW-MRIIL21IL26pancreatic cancertumor microenvironment

Identifiers

PMID31948053
PMCPMC6982276
OpenAlexW2998315299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.