Evidence map›Paper›PMID 31947729›Full record

ArticlePolymers2020

pH/Reduction Dual-Stimuli-Responsive Cross-Linked Micelles Based on Multi-Functional Amphiphilic Star Copolymer: Synthesis and Controlled Anti-Cancer Drug Release.

Yunwei Huang, Jingye Yan, Shiyuan Peng, Zilun Tang, Cuiying Tan, Jiabao Ling, Wenjing Lin, Xiaofeng Lin, Xihong Zu, Guobin Yi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yunwei HuangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Jingye YanSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Shiyuan PengGuangdong Provincial Key Lab of Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Zilun TangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Cuiying TanSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Jiabao LingSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Wenjing LinSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.ORCID 0000-0003-4715-9839
Xiaofeng LinSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Xihong ZuSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Guobin YiSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.ORCID 0000-0002-4032-4611
Guangdong University of Technology · CNSouth China University of Technology · CN

Funding

Guangdong Provincal Key Laboratory of Advanced Coatings Research and Development 2017B030314105National Natural Science Foundation of China 21808039National Natural Science Foundation of China 51873042Natural Science Foundation of Guangdong Province 2018A030310525Science and Technology Planning Project of Guangdong Province 2017B090915004
6 · The paper itself

Abstract

Novel approach has been constructed for preparing the amphiphilic star copolymer pH/reduction stimuli-responsive cross-linked micelles (SCMs) as a smart drug delivery system for the well-controlled anti-tumor drug doxorubicin (DOX) release. The SCMs had a low CMC value of 5.3 mg/L. The blank and DOX-loaded SCMs both had a spherical shape with sizes around 100-180 nm. In addition, the good stability and well pH/reduction-sensitivity of the SCMs were determined by dynamic light scattering (DLS) as well. The SCMs owned a low release of DOX in bloodstream and normal tissues while it had a fast release in tumor higher glutathione (GSH) concentration and/or lower pH value conditions, which demonstrates their pH/reduction dual-responsiveness. Furthermore, we conducted the thermodynamic analysis to study the interactions between the DOX and polymer micelles in the DOX release process. The values of the thermodynamic parameters at pH 7.4 and at pH 5.0 conditions indicated that the DOX release was endothermic and controlled mainly by the forces of an electrostatic interaction. At pH 5.0 with 10 mM GSH condition, electrostatic interaction, chemical bond, and hydrophobic interactions contributed together on DOX release. With the low cytotoxicity of blank SCMs and well cytotoxicity of DOX-loaded SCMs, the results indicated that the SCMs could form a smart cancer microenvironment-responsive drug delivery system. The release kinetic and thermodynamic analysis offer a theoretical foundation for the interaction between drug molecules and polymer matrices, which helps provide a roadmap for the oriented design and control of anti-cancer drug release for cancer therapy.

Indexed as

cross-linked micellesdrug deliverydual-responsiverelease kineticsrelease thermodynamics

Identifiers

PMID31947729
PMCPMC7023672
OpenAlexW2998443192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.