Evidence map›Paper›PMID 31947683›Full record

ReviewGenes2020

Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis.

Rosella Mechelli, Renato Umeton, Grazia Manfrè, Silvia Romano, Maria Chiara Buscarinu, Virginia Rinaldi, Gianmarco Bellucci, Rachele Bigi, Michela Ferraldeschi, Marco Salvetti and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Oxidative Stress Markers in Multiple Sclerosis.International journal of molecular sciences · 2024
    Review
  3. Association betweenInternational journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Rosella MechelliSan Raffaele Roma Open University and IRCCS San Raffaele Pisana, 00166 Rome, Italy.
Renato UmetonDepartment of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Grazia ManfrèSan Raffaele Roma Open University and IRCCS San Raffaele Pisana, 00166 Rome, Italy.
Silvia RomanoCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Maria Chiara BuscarinuCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Virginia RinaldiCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Gianmarco BellucciCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Rachele BigiCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Michela FerraldeschiCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Marco SalvettiCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Giovanni RistoriCentre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.
Sapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITHarvard University · USIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies have identified more than 200 multiple sclerosis (MS)-associated loci across the human genome over the last decade, suggesting complexity in the disease etiology. This complexity poses at least two challenges:

Indexed as

Gene-Environment InteractionGenetic Predisposition to DiseaseGenome, HumanMultiple SclerosisPolymorphism, Single NucleotideQuantitative Trait LociGenome-Wide Association StudyHumansexpression quantitative trait loci (eQTL), protein–protein interactiongene-environment interactiongenome wide association studiesmultiple sclerosispathway analysispolygenic risk score

Identifiers

PMID31947683
PMCPMC7017269
OpenAlexW3000278810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.