Evidence map›Paper›PMID 31947679›Full record

ArticleInternational journal of molecular sciences2020

Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K

Daniel Bustos, Mauricio Bedoya, David Ramírez, Guierdy Concha, Leandro Zúñiga, Niels Decher, Erix W Hernández-Rodríguez, Francisco V Sepúlveda, Leandro Martínez, Wendy González

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain KProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Daniel BustosCentro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca 3460000, Chile.
Mauricio BedoyaCentro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca 3460000, Chile.
David RamírezInstituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago 8380453, Chile.
Guierdy ConchaCentro de Investigaciones Médicas, Escuela de Medicina, Universidad de Talca, Talca 3460000, Chile.
Leandro ZúñigaCentro de Investigaciones Médicas, Escuela de Medicina, Universidad de Talca, Talca 3460000, Chile.
Niels DecherInstitute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, D-35037 Marburg, Germany.
Erix W Hernández-RodríguezEscuela de Química y Farmacia, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.
Francisco V SepúlvedaCentro de Estudios Científicos (CECs), Avenida Arturo Prat 514, Valdivia 5110466, Chile.
Leandro MartínezInstitute of Chemistry and Center for Computing in Engineering & Science, University of Campinas, Campinas 13083-861, SP, Brazil.
Wendy GonzálezCentro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca 3460000, Chile.
University of Talca · CLCatholic University of the Maule · CLCentro de Estudios Científicos · CLPhilipps University of Marburg · DEUniversidad Autónoma de Chile · CLUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Comisión Nacional de Investigación Científica y Tecnológica FONDEQUIP EQM160063Fondo Nacional de Desarrollo Científico y Tecnológico 1191133
6 · The paper itself

Abstract

Two-pore domain potassium (K

Indexed as

Hydrogen-Ion ConcentrationAmino Acid SequenceBinding SitesHEK293 CellsHumansIon Channel GatingIonsMolecular Docking SimulationMolecular Dynamics SimulationPotassium Channels, Tandem Pore DomainProtein BindingProtein ConformationStructure-Activity RelationshipIonsKCNK5 protein, humanPotassium Channels, Tandem Pore Domainhomology modelingK2P channelsmodeling of protein dynamicsstructure–function relationshipsTASK-2 channels

Identifiers

PMID31947679
PMCPMC7013731
OpenAlexW2998940007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.