Evidence map›Paper›PMID 31947657›Full record

ArticleCells2020

Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice.

Marangelie Criado-Marrero, Jonathan J Sabbagh, Margaret R Jones, Dale Chaput, Chad A Dickey, Laura J Blair

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  8. DnaJs are enriched in tau regulators.International journal of biological macromolecules · 2023
    Article
  9. Deregulated Transcription and Proteostasis in AdultInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Liquid-liquid phase separation of tau: From molecular biophysics to physiology and disease.Protein science : a publication of the Protein Society · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marangelie Criado-MarreroDepartment of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA.
Jonathan J SabbaghDepartment of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA.
Margaret R JonesDepartment of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA.
Dale ChaputDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.
Chad A DickeyDepartment of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA.
Laura J BlairDepartment of Molecular Medicine, USF Health Byrd Institute, University of South Florida, Tampa, FL 33613, USA.
University of South Florida · US

Funding

The Hsp90 cochaperone FKBP51 regulates tau structure and functionR01NS073899 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI Laura J Blair · 2011 to 2026
$6.9M
Modeling stress-related psychopathology through FKBP5 manipulationR01MH103848 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI BLAIR, LAURA J · 2014 to 2018
$1.9M
NIMH NIH HHS R01 MH103848NINDS NIH HHS R01 NS073899
6 · The paper itself

Abstract

Tau dysfunction is common in several neurodegenerative diseases including Alzheimer's disease (AD) and frontotemporal dementia (FTD). Affective symptoms have often been associated with aberrant tau pathology and are commonly comorbid in patients with tauopathies, indicating a connection between tau functioning and mechanisms of depression. The current study investigated depression-like behavior in

Indexed as

NeurogenesisAnimalsDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutNeuronstau ProteinsMapt protein, mousetau ProteinsAlzheimer’s diseasedepressionglucocorticoid receptorhippocampal neurogenesisstresstauopathies

Identifiers

PMID31947657
PMCPMC7016791
OpenAlexW2999513790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.