Evidence map›Paper›PMID 31947642›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in

Rafael Pereira da Cruz, Thiago Sampaio de Freitas, Maria do Socorro Costa, Antonia Thassya Lucas Dos Santos, Fábia Ferreira Campina, Raimundo Luiz Silva Pereira, José Weverton Almeida Bezerra, Lucindo José Quintans-Júnior, Adriano Antunes De Souza Araújo, José Pinto De Siqueira Júnior and 5 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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  15. Inhibition ofBioMed research international · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Rafael Pereira da CruzDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Thiago Sampaio de FreitasDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Maria do Socorro CostaDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Antonia Thassya Lucas Dos SantosDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Fábia Ferreira CampinaDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Raimundo Luiz Silva PereiraDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
José Weverton Almeida BezerraDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Lucindo José Quintans-JúniorDepartment of Physiology, Federal University of Sergipe, São Cristóvão, 49100-000 Sergipe, Brazil.
Adriano Antunes De Souza AraújoDepartment of Physiology, Federal University of Sergipe, São Cristóvão, 49100-000 Sergipe, Brazil.
José Pinto De Siqueira JúniorDepartment of Molecular Biology, Federal University of Paraíba, João Pessoa, 58051-900 Paraíba, Brazil.
Marcello IritiDepartment of Agricultural and Environmental Sciences, Milan State University, 20133 Milan, Italy.
Elena Maria VaroniDepartment of Biomedical, Surgical and Dental Sciences, Milan State University, 20142 Milan, Italy.
Irwin Rose Alencar De MenezesDepartment of Biological Chemistry, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Henrique Douglas Melo CoutinhoDepartment of Biological Chemistry, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Maria Flaviana Bezerra Morais-BragaDepartment of Biological Sciences, Regional University of Cariri, Crato, 63105-000 Ceará, Brazil.
Universidade Regional do Cariri · BRUniversidade Federal de Sergipe · BRUniversity of Milan · ITUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. α-Bisabolol is a sesquiterpene isolated from several plants such as

Indexed as

antibioticsbacteriaresistancesesquiterpene

Identifiers

PMID31947642
PMCPMC7168184
OpenAlexW3000397730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.