Evidence map›Paper›PMID 31947640›Full record

ArticleGenes2020

Identification of a Novel Imprinted Transcript in the Porcine

Jinsoo Ahn, Huiguang Wu, Joonbum Lee, In-Sul Hwang, Debing Yu, Jin-Seop Ahn, Jeong-Woong Lee, Seongsoo Hwang, Kichoon Lee

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Loss of Monoallelic Expression ofFrontiers in genetics · 2022
    Article
  8. Genomic Imprinting at the PorcineAnimals : an open access journal from MDPI · 2021
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Jinsoo AhnFunctional Genomics Laboratory, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.
Huiguang WuFunctional Genomics Laboratory, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.
Joonbum LeeFunctional Genomics Laboratory, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.
In-Sul HwangAnimal Biotechnology Division, National Institute of Animal Science, RDA, Jeonbuk 55365, Korea.
Debing YuFunctional Genomics Laboratory, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.
Jin-Seop AhnBiotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Jeong-Woong LeeBiotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Seongsoo HwangAnimal Biotechnology Division, National Institute of Animal Science, RDA, Jeonbuk 55365, Korea.
Kichoon LeeFunctional Genomics Laboratory, Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · USNational Institute of Animal Science · KRNanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic imprinting in domestic animals contributes to the variance of performance traits. However, research remains to be done on large-scale detection of epigenetic landscape of porcine imprinted loci including the GNAS complex locus. The purpose of this study was to generate porcine parthenogenetic fetuses and comprehensively identify imprinting patterns of the GNAS locus in transcript levels. To this end, both normally fertilized and bimaternal (uniparental) parthenogenetic porcine fetuses were generated, and whole genome bisulfite sequencing (WGBS) and RNA sequencing (RNA-seq) were performed to construct methylome and transcriptome, respectively. Differentially methylated regions (DMRs) between the fetuses were identified through methylome analysis, and parental-origin-specific expression patterns of transcripts were examined with transcriptome. As a result, three major DMRs were identified: paternally methylated

Indexed as

AnimalsBase SequenceDNA MethylationEpigenesis, GeneticEpigenomeExonsFetusGenomeGenomic ImprintingGTP-Binding Protein alpha Subunits, GsParthenogenesisPromoter Regions, GeneticSequence Analysis, RNASwineTranscriptomeGTP-Binding Protein alpha Subunits, Gsdifferentially methylated regionfetusgenomic imprintingGNASparthenogeneticparthenoteporcineRNA-sequencingwhole genome bisulfite sequencing

Identifiers

PMID31947640
PMCPMC7017182
OpenAlexW3000574604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.