Evidence map›Paper›PMID 31947623›Full record

ArticleCells2020

Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer.

Mercedes Marín-Aguilera, Natalia Jiménez, Òscar Reig, Ruth Montalbo, Ajit K Verma, Giancarlo Castellano, Lourdes Mengual, Iván Victoria, María V Pereira, Maria Milà-Guasch and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  18. Molecular mechanisms of docetaxel resistance in prostate cancer.Cancer drug resistance (Alhambra, Calif.) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Mercedes Marín-AguileraTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Natalia JiménezTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Òscar ReigTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Ruth MontalboTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Ajit K VermaDepartment of Human Oncology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Giancarlo CastellanoGenomic Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Lourdes MengualDepartment and Laboratory of Urology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre de Recerca Biomèdica CELLEX, 08036 Barcelona, Spain.
Iván VictoriaFundació Clínic per a la Recerca Biomèdica, 08036 Barcelona, Spain.
María V PereiraFundació Clínic per a la Recerca Biomèdica, 08036 Barcelona, Spain.
Maria Milà-GuaschTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Susana García-RecioTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Daniel Benítez-RibasImmunology Department, Hospital Clínic, 08036 Barcelona, Spain.
Raquel CabezónImmunology Department, Hospital Clínic, 08036 Barcelona, Spain.
Azucena GonzálezImmunology Department, Hospital Clínic, 08036 Barcelona, Spain.
Manel JuanImmunology Department, Hospital Clínic, 08036 Barcelona, Spain.
Aleix PratTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Begoña MelladoTranslational Genomics Group and Targeted Therapeutics in Solid Tumors, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Hospital Clínic de Barcelona · ESFundació Clínic per a la Recerca Biomèdica · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether the expression of AR full-length

Indexed as

AdultAgedCell Line, TumorGenetic VariationHumansLeukocytes, MononuclearMaleMiddle AgedNeoplastic Cells, CirculatingPC-3 CellsProstatic Neoplasms, Castration-ResistantReceptors, AndrogenRNA, MessengerYoung AdultAR protein, humanReceptors, AndrogenRNA, Messengerabirateroneandrogen receptorandrogen receptor splicing variant 7castration-resistant prostate cancerenzalutamideperipheral blood mononuclear cellstaxanes

Identifiers

PMID31947623
PMCPMC7016895
OpenAlexW2999696170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.