Evidence map›Paper›PMID 31947528›Full record

ReviewNutrients2020

Sarcopenia and Heart Failure.

Francesco Curcio, Gianluca Testa, Ilaria Liguori, Martina Papillo, Veronica Flocco, Veronica Panicara, Gianluigi Galizia, David Della-Morte, Gaetano Gargiulo, Francesco Cacciatore and 3 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298825 (Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure), which is not on this map. Cited by 143 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 11 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06298825 unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure: a Prospective, Multi-center, Observational Cohort Study

TypeobservationalSponsorGuangdong Provincial People's HospitalRan2024 to 2026Enrolled500ConditionsAcute Decompensated Heart Failure
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 11 syntheses or guidelines pooled it, 246 citations in OpenAlex.

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  18. A cardiovascular-motor axis framework for perfusion-mediated motor impairment.International journal of cardiology. Heart & vasculature · 2026
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Francesco CurcioDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Gianluca TestaDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Ilaria LiguoriDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Martina PapilloDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Veronica FloccoDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Veronica PanicaraDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Gianluigi GaliziaDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
David Della-MorteDepartment of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy.
Gaetano GargiuloDivision of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, 84121 Salerno, Italy.
Francesco CacciatoreDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Domenico BonaduceDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
Francesco LandiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, 00100 Rome, Italy.
Pasquale AbeteDepartment of Translational Medical Sciences, University of Naples Federico II Naples, 80131 Naples, Italy.
University of Naples Federico II · ITFondazione Salvatore Maugeri · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITSan Raffaele University of Rome · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modifications of lean mass are a frequent critical determinant in the pathophysiology and progression of heart failure (HF). Sarcopenia may be considered one of the most important causes of low physical performance and reduced cardiorespiratory fitness in older patients with HF. Sarcopenia is frequently misdiagnosed as cachexia. However, muscle wasting in HF has different pathogenetic features in sarcopenic and cachectic conditions. HF may induce sarcopenia through common pathogenetic pathways such as hormonal changes, malnutrition, and physical inactivity; mechanisms that influence each other. In the opposite way, sarcopenia may favor HF development by different mechanisms, including pathological ergoreflex. Paradoxically, sarcopenia is not associated with a sarcopenic cardiac muscle, but the cardiac muscle shows a hypertrophy which seems to be "not-functional." First-line agents for the treatment of HF, physical activity and nutritional interventions, may offer a therapeutic advantage in sarcopenic patients irrespective of HF. Thus, sarcopenia is highly prevalent in patients with HF, contributing to its poor prognosis, and both conditions could benefit from common treatment strategies based on pharmacological, physical activity, and nutritional approaches.

Indexed as

AgedAged, 80 and overFemaleHeartHeart FailureHumansHypertrophyMaleMuscle, SkeletalMuscular AtrophyNutritional StatusPrognosisSarcopeniacachexiaelderlyheart failuremalnutritionphysical activitysarcopenia

Identifiers

PMID31947528
PMCPMC7019352
OpenAlexW2999115344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.