Evidence map›Paper›PMID 31947172›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2019

Drug-Specific Models Improve the Performance of an EEG-based Automated Brain-State Prediction System.

Kimia Kashkooli, Sam L Polk, Shubham Chamadia, Eunice Hahm, Breanna Ethridge, Jacob Gitlin, Reine Ibala, Jennifer Mekonnen, Juan Pedemonte, James M Murphy and 3 more

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kimia Kashkooli
Sam L Polk
Shubham Chamadia
Eunice Hahm
Breanna Ethridge
Jacob Gitlin
Reine Ibala
Jennifer Mekonnen
Juan Pedemonte
James M Murphy
Haoqi Sun
M Brandon Westover
Oluwaseun Akeju
Massachusetts General Hospital · USTufts University · USHarvard University · USPontificia Universidad Católica de Chile · CL

Funding

Pathophysiology of postoperative delirium and the use of biomimetic sleep as a treatment strategy in the CSICUR01AG053582 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON-AKEJU, OLUWASEUN · 2016 to 2020
$4.0M
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)R01NS102190 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$3.2M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
NIA NIH HHS R01 AG053582NINDS NIH HHS R01 NS102190NINDS NIH HHS R01 NS107291
6 · The paper itself

Abstract

Maintaining anesthetic states using automated brain-state prediction systems is expected to reduce drug overdosage and associated side-effects. However, commercially available brain-state monitoring systems perform poorly on drug-class combinations. We assume that current automated brain-state prediction systems perform poorly because they do not account for brain-state dynamics that are unique to drug-class combinations. In this work, we develop a k-nearest neighbors model to test whether improvements to automated brain-state prediction of drug-class combinations are feasible. We utilize electroencephalogram data collected from human subjects who received general anesthesia with sevoflurane and general anesthesia with the drug-class combination of sevoflurane-plus-ketamine. We demonstrate improved performance predicting anesthesia-induced brain-states using drug-specific models.

Indexed as

Anesthetics, InhalationBrainAnesthesia, GeneralElectroencephalographyHumansMethyl EthersAnesthetics, InhalationMethyl Ethers

Identifiers

PMID31947172
PMCPMC7077760
OpenAlexW2979551900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.