Network Activity Due to Topographic Organization of Schaffer Collaterals in a Large-Scale Model of Rat CA1.

Connectivity between neural regions, particularly in the hippocampus, is seldom all-to-all or random, yet it is the predominant method by which connectivity is implemented in most models of neuronal networks. We have been developing a computational platform for simulating the trisynaptic circuit of rat hippocampus with which we have constructed a large-scale, biologically-realistic, spiking neuronal network model of the entorhinal-dentate-CA3 system. Using the model, we had demonstrated a non-trivial effect of topographic connectivity on network dynamics and function. In this work, we detail the introduction of the CA1 subregion to the large-scale model. Using anatomical data, we constrained the distribution of axon collaterals, i.e., Schaffer collaterals, projected from CA3 to CA1 and preserved the topographic organization of the projections. Using a simplified multi-compartmental model of CA1 pyramidal cells and a single compartment model of CA1 parvalbumin basket cells, that were connected with disynaptic feedforward inhibition and feedback inhibition, we demonstrate the network activity of the CA1 network given a topographic organization of Schaffer collaterals. From this introduction of CA1 to the large-scale model, we can then observe the successive transformation of spatio-temporal, spiking neural activity as it propagates through the trisynaptic circuit.