ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2019
Effects of Hydrogel-Fiber on Cystic Cavity after Spinal Cord Injury.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice.Molecular neurobiology · 2024Article
- Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury.Military Medical Research · 2022Review
- Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy.Oxidative medicine and cellular longevity · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spinal cord injury (SCI) affects millions of people around the world, however, functional recovery is far from satisfying. The continuous emergence of biomaterials provides a new idea for the repair of SCI. Hydrogels can mimic the extracellular matrix (ECM), however, the unstable hydrogel shape limits its application. In this study, we evaluate the effect of hydrogel fiber (Polycaprolactone, PCL fiber was added to the hydrogel) on the recovery after SCI. 20 adult male Wistar rats were randomly divided into 4 groups: SCI+hydrogel group (H), SCI+hydrogel + PCL fiber group (HF), SCI group (SCI) and SHAM group (SHAM) and (N=5). SCI contusion injury was induced by a MASCIS Impactor (20g weight, 50cm high) at the T9 level in rats. Hydrogels or PCL fiber were administered into the SCI site one week after surgery. Periodical Basso, Beattie, and Bresnahan (BBB) locomotor score, spinal cord hematoxylin and eosin stain (HE) staining, and immunofluorescence staining were performed 28 days after the operation. HE staining showed that the average cystic cavity area in SCI (20.78 ±2.93 mm
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Registered trials
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