Evidence map›Paper›PMID 31945762›Full record

GuidelineObesity facts2020

OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions.

Maud Alligier, Romain Barrès, Ellen E Blaak, Yves Boirie, Jildau Bouwman, Paul Brunault, Kristina Campbell, Karine Clément, I Sadaf Farooqi, Nathalie J Farpour-Lambert and 22 more

Open access · goldAbstract readPractice Guideline
In one paragraph

Guideline in Obesity facts, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  7. Review
  8. Review
  9. Article
  10. Review
  11. A review of harmonization methods for studying dietary patterns.Smart health (Amsterdam, Netherlands) · 2022
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 14 countries.

Maud AlligierFCRIN/FORCE Network, Centre de Recherche en Nutrition Humaine Rhône-Alpes, Lyon, France.
Romain BarrèsNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ellen E BlaakDepartment of Human Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Yves BoirieUniversity Clermont Auvergne, CHU Clermont-Ferrand, Clinical Nutrition Department, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.
Jildau BouwmanTNO (Netherlands Organization for Applied Scientific Research), Microbiology and Systems Biology, Zeist, The Netherlands.
Paul BrunaultEquipe de Liaison et de Soins en Addictologie, CHRU de Tours, and UMR 1253, iBrain, Université de Tours, Inserm, and Qualipsy EE 1901, Université de Tours, Tours, France.
Kristina CampbellKC Microbiome Communications Group, Victoria, British Columbia, Canada.
Karine ClémentSorbonne University/INSERM, Nutrition and Obesities, Systemic Approaches Research Unit, and Assistance Publique Hôpitaux de Paris, Nutrition Department, Pitié-Salpêtrière Hospital, Paris, France.
I Sadaf FarooqiWellcome-MRC Institute of Metabolic Science and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.
Nathalie J Farpour-LambertObesity Prevention and Care Program Contrepoids, Service of Therapeutic Education for Chronic Diseases, Department of Community Health, Primary Care and Emergency, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Gema FrühbeckDepartment of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra & CIBEROBN, IdiSNA, Pamplona, Spain.
Gijs H GoossensDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Jorg HagerMetabolic Phenotyping, Nestlé Institute of Health Sciences, Lausanne, Switzerland.
Jason C G HalfordPsychological Sciences, University of Liverpool, Liverpool, United Kingdom.
Hans HaunerInstitute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
David JacobiL'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
Chantal JuliaNutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center (CRESS), Inra, Cnam, Paris 13 University and Public Health Department, Avicenne Hospital, AP-HP, Bobigny, France.
Dominique LanginInstitute of Metabolic and Cardiovascular Diseases, I2MC, Inserm, Paul Sabatier University, and Department of Medical Biochemistry, Toulouse University Hospitals, Toulouse, France.
Andrea NataliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Martin NeoviusDepartment of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.
Jean Michel OppertDepartment of Nutrition, Pitié-Salpêtrière Hospital (AP-HP), Sorbonne University, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.
Uberto PagottoDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Policlinic S. Orsola, Endocrinology Unit, Bologna, Italy.
Antonio L PalmeiraCIPER, PANO-SR, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.
Helen RocheNutrigenomics Research Group, UCD Institute of Food & Health, University College Dublin, Dublin, Ireland.
Mikael RydénDepartment of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
André J ScheenLiège University, Division of Diabetes, Nutrition and Metabolic Disorders, CHU Liège, Liège, Belgium.
Chantal SimonCarMen Laboratory, INSERM 1060, INRA 1397, University of Lyon, Oullins, France.
Thorkild I A SorensenNovo Nordisk Foundation Center for Basic Metabolic Research, and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Luc TappyPhysiology Department, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Hannele Yki-JärvinenUniversity of Helsinki, Helsinki University Hospital, and Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Olivier ZieglerDepartment of Endocrinology, Diabetes and Nutrition, Hôpital Brabois Adultes, CHRU de Nancy, Vandoeuvre Lès Nancy, France.
Martine LavilleFCRIN/FORCE Network, Centre de Recherche en Nutrition Humaine Rhône-Alpes, Université de Lyon, Hospices Civils de Lyon, Lyon, France, martine.laville@univ-lyon1.fr.
Maastricht University Medical Centre · NLSorbonne Université · FRUniversité Claude Bernard Lyon 1 · FRUniversity of Copenhagen · DKCapital Regional District · CACentre Hospitalier Régional et Universitaire de Nancy · FRCentre National de la Recherche Scientifique · FRClinica Universidad de Navarra · ESInserm · FRInstitut National Polytechnique de Toulouse · FRKarolinska Institutet · SEKarolinska University Hospital · SENestlé (Switzerland) · CHNetherlands Organisation for Applied Scientific Research · NLSt Thomas' Hospital · GBTUM Klinikum · DEUnité de Nutrition Humaine · FRUniversité de Tours · FRUniversité Toulouse III - Paul Sabatier · FRUniversity College Dublin · IE

Funding

Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/5
6 · The paper itself

Abstract

Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes.

Indexed as

Biological Variation, PopulationExpert TestimonyChoice BehaviorDietEuropeHumansMedical History TakingObesityPrognosisRandomized Controlled Trials as TopicResearch DesignInterventionsObesityPrecision medicineStratificationVariables

Identifiers

PMID31945762
PMCPMC7098277
OpenAlexW3000306887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.