ArticleJournal of clinical hypertension (Greenwich, Conn.)2020
Choroidal thickness is associated with renal hemodynamics in essential hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Retinal Diseases: Mechanisms, Diagnosis and Treatments-From Mechanistic Insights to Personalized Retina Care.Journal of personalized medicine · 2026Article
- Diagnostic Value of Ocular Hemodynamics and Choroidal Thickness in Unilateral Sudden Sensorineural Hearing Loss: Non-Invasive Biomarkers of Systemic Microvascular Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Renal Resistive Index and Cardiovascular Events, Cardiovascular Mortality, and All-Cause Mortality: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2025Article
- Exudative retinal detachment and hypertensive choroidopathy in a patient with suspected HELLP syndrome: a case report.BMC ophthalmology · 2025Article
- Renal Resistive Index from Renal Hemodynamics to Cardiovascular Risk: Diagnostic, Prognostic, and Therapeutic Implications.Diseases (Basel, Switzerland) · 2025Review
- Renal Resistive Index and 10-Year Risk of Cardiovascular Disease Predicted by Framingham Risk Score and Pooled Cohort Equations: An Observational Study in Hypertensive Individuals Without Cardiovascular Disease.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Observational
- Relationship Between Short-Term Blood Pressure Variability and Choroidal-Retinal Thicknesses Assessed by Optical Coherence Tomography in Hypertensive Subjects.Journal of personalized medicine · 2024Article
- Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography.International journal of ophthalmology · 2024Article
- Evaluation of subclinical changes in recently diagnosed pediatric hypertension patients without hypertensive retinopathy: an OCT study.International ophthalmology · 2023Article
- Choroidal Assessment in Patients with Type 2 Diabetes Mellitus and Non-Proliferative Diabetic Retinopathy by Swept-Source Ocular Coherence Tomography and Image Binarization.Medicina (Kaunas, Lithuania) · 2022Article
- Comparison of Each Retinal Layer Thicknesses between Eyes with Central Retinal Vein Occlusion and Normal Contralateral Eyes.Korean journal of ophthalmology : KJO · 2022Article
- Choroidal vascularity index of patients with coronary artery disease.Scientific reports · 2022Article
- The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease.International journal of endocrinology · 2022Article
- Choroidal Vascularity Index Assessment: A Potential Noninvasive Technique for Diagnosing Diabetic Nephropathy.Journal of ophthalmology · 2022Article
- Comparison of choroidal thickness in systemic hypertensive subjects with healthy individuals by spectral domain optical coherence tomography.Indian journal of ophthalmology · 2021Article
- Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Renal resistive index: Beyond the hemodynamics.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Choroidal thickness is associated with renal hemodynamics in essential hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Choroidal thickness in patients with systemic arterial hypertension: a systematic review and meta-analysis.Therapeutic advances in ophthalmologyArticle
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The choroid is the most vascularized structure of the eye and plays a central role in the development of the retinal vascular changes that occur in arterial hypertension. Changes of choroidal thickness (ChT) assessed by optical coherence tomography (OCT) technology could reflect the vascular complications of hypertension. Also, intrarenal hemodynamic damage, associated with endothelial dysfunction, demonstrated to be a good indicator of systemic morphofunctional arterial impairment. The aim of this study is to assess the relationship between ChT and renal hemodynamics in subjects with essential hypertension. Routine laboratory tests, clinical history, and physical examination, including blood pressure assessment, were performed in 90 subjects with essential hypertension. All patients underwent Doppler ultrasonographic evaluation of intra-renal hemodynamics and OCT imaging to assess ChT. When subjects were divided in two groups based on renal resistive index (RRI), group I (RRI ≥ 75% percentile) showed significantly lower values of ChT than group II (RRI < 75% percentile) (P < .001). When divided in two groups based on the ChT median values, patients with lower ChT had significantly higher RRI values than those with ChT above the median values (P < .05). In multivariate model including age, eGFR, and other variables as confounding factors, RRI ≥ 75% was independently associated with ChT. ChT was significantly correlated with renal resistive index in subjects with essential hypertension, confirmed in multivariate analyses. This result could be referred to changes in vascular elastic properties that occur in retinal and intrarenal vascular system probably due to oxidative stress and endothelial dysfunction commonly found in early complications of hypertension.
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