ReviewAngewandte Chemie (International ed. in English)2021
Coenzymes and Their Role in the Evolution of Life.
Review in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 104 citations in OpenAlex.
- Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent.Science advances · 2026Article
- A Nonenzymatic Analogue of the Biosynthesis of Pyridoxal Vitamers.Journal of the American Chemical Society · 2026Article
- A Vibrational Analysis of Pyridoxal 5'-Phosphate Derivatives: Pyridoxal 5'-Phosphate-isopropylamine and Pyridoxal 5'-Phosphate-(The journal of physical chemistry. B · 2026Article
- A new LUCApedia database for data-driven research on early evolutionary history.Bioinformatics advances · 2026Article
- Coenzyme-protein interactions since early life.eLife · 2025Article
- Molecular Carrier-Assisted Self-Assembly ofACS applied materials & interfaces · 2025Article
- On the emergence of metabolism: the evolution of proteins that powered life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Conversion of pyridoxal to pyridoxamine with NHThe FEBS journal · 2025Article
- Protometabolic functions of pyridoxal: A link between early amino acid synthesis and enzyme evolution.The FEBS journal · 2025Article
- Syntheses of optically active monapterin, 7,8-dihydromonapterin, and 5,6,7,8-tetrahydromonapterin from l-xylose.RSC advances · 2024Article
- On the aqueous origins of the condensation polymers of life.Nature reviews. Chemistry · 2024Review
- NArchives of microbiology · 2024Article
- Coenzymes in a pre-enzymatic metabolism.Science advances · 2024Review
- Nicotinamide Riboside: What It Takes to Incorporate It into RNA.Molecules (Basel, Switzerland) · 2024Review
- Peptides En Route from Prebiotic to Biotic Catalysis.Accounts of chemical research · 2024Article
- Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism.RSC chemical biology · 2024Review
- Prebiotic access to enantioenriched amino acids via peptide-mediated transamination reactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolution at the Origins of Life?Life (Basel, Switzerland) · 2024Review
- Shining a Spotlight on Methyl Groups: Photochemically Induced Dynamic Nuclear Polarization Spectroscopy of 5-Deazariboflavin and Its Nor Analogs.International journal of molecular sciences · 2024Article
- Integrative Approach to Probe Alternative Redox Mechanisms in RNA Modifications.Accounts of chemical research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of coenzymes, or their impact on the origin of life, is fundamental for understanding our own existence. Having established reasonable hypotheses about the emergence of prebiotic chemical building blocks, which were probably created under palaeogeochemical conditions, and surmising that these smaller compounds must have become integrated to afford complex macromolecules such as RNA, the question of coenzyme origin and its relation to the evolution of functional biochemistry should gain new impetus. Many coenzymes have a simple chemical structure and are often nucleotide-derived, which suggests that they may have coexisted with the emergence of RNA and may have played a pivotal role in early metabolism. Based on current theories of prebiotic evolution, which attempt to explain the emergence of privileged organic building blocks, this Review discusses plausible hypotheses on the prebiotic formation of key elements within selected extant coenzymes. In combination with prebiotic RNA, coenzymes may have dramatically broadened early protometabolic networks and the catalytic scope of RNA during the evolution of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.