Evidence map›Paper›PMID 31945115›Full record

ArticlePloS one2020

Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools.

Kathleen M Akgün, Keith Sigel, Kei-Hoi Cheung, Farah Kidwai-Khan, Alex K Bryant, Cynthia Brandt, Amy Justice, Kristina Crothers

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. Gender Reference Use in Spirometry for Transgender Patients.Annals of the American Thoracic Society · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kathleen M AkgünDepartment of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States of America.ORCID 0000-0003-2623-7463
Keith SigelDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Kei-Hoi CheungDepartment of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States of America.
Farah Kidwai-KhanDepartment of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States of America.
Alex K BryantDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America.
Cynthia BrandtDepartment of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States of America.
Amy JusticeDepartment of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States of America.
Kristina CrothersDepartment of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, United States of America.
Yale University · USIcahn School of Medicine at Mount Sinai · USUniversity of Michigan · USUniversity of Washington · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Integrated Stepped Care for Unhealthy Alcohol Use in HIVU01AA020795 · NIAAA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2011 to 2020
$5.2M
Benefits and Harms of Lung Cancer Screening in HIV InfectionR01CA173754 · NCI · UNIVERSITY OF WASHINGTON · PI BRAITHWAITE, RONALD SCOTT, CROTHERS, KRISTINA ANNE · 2013 to 2017
$2.5M
Optimizing Lung Cancer Treatment in HIV Infected PersonsR01CA210806 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIGEL, KEITH MAGNUS · 2017 to 2020
$2.3M
Consortium to improve Outcomes in HIV/AIDS, Alcohol, Aging & multi-Substance useU01AA020799 · NIAAA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRAITHWAITE, RONALD SCOTT · 2011 to 2020
$2.1M
The Cost-Effectiveness of Lung Cancer Screening in HIV InfectionK07CA180782 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIGEL, KEITH MAGNUS · 2014 to 2018
$646k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K07 CA180782NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA173754NCI NIH HHS R01 CA210806NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01 AA020795NIAAA NIH HHS U01 AA020799NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is associated with poor quality of life, hospitalization and mortality. COPD phenotype includes using pulmonary function tests to determine airflow obstruction from the forced expiratory volume in one second (FEV1):forced vital capacity. FEV1 is a commonly used value for severity but is difficult to identify in structured electronic health record (EHR) data. DATA SOURCE AND

methodsUsing the Microsoft SQL Server's full-text search feature and string functions supporting regular-expression-like operations, we developed an automated tool to extract FEV1 values from progress notes to improve ascertainment of FEV1 in EHR in the Veterans Aging Cohort Study (VACS).

resultsThe automated tool increased quantifiable FEV1 values from 12,425 to 16,274 (24% increase in numeric FEV1). Using chart review as the reference, positive predictive value of the tool was 99% (95% Confidence interval: 98.2-100.0%) for identifying quantifiable FEV1 values and a recall value of 100%, yielding an F-measure of 0.99. The tool correctly identified FEV1 measurements in 95% of cases.

conclusionA SQL-based full text search of clinical notes for quantifiable FEV1 is efficient and improves the number of values available in VA data. Future work will examine how these methods can improve phenotyping of patients with COPD in the VA.

Indexed as

Cohort StudiesData MiningElectronic Health RecordsForced Expiratory VolumeHealth Information SystemsHospitalizationHumansLungNatural Language ProcessingPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSoftwareUnited StatesUnited States Department of Veterans AffairsVeteransVital Capacity

Identifiers

PMID31945115
PMCPMC6964890
OpenAlexW2999219102

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.