Trial reportCirculation. Arrhythmia and electrophysiology2020
RADAR: A Multicenter Food and Drug Administration Investigational Device Exemption Clinical Trial of Persistent Atrial Fibrillation.
Trial report in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03263702 (Real-time Electrogram Analysis for Drivers of AtRial Fibrillation), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Real-time Electrogram Analysis for Drivers of AtRial Fibrillation (RADAR)
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Prospective Trial of Radiofrequency Catheter Ablation of High Dominant Frequencies After Pulmonary Vein Isolation in Non-Paroxysmal Atrial Fibrillation (PAD-AF Trial): A Multicenter, Randomized Clinical Trial.Journal of cardiovascular electrophysiology · 2026Trial
- Catheter Ablation With Morphologic Repetitiveness Mapping for Persistent Atrial Fibrillation.JAMA network open · 2023Trial
- Integrated Management of Persistent Atrial Fibrillation.Biomedicines · 2025Review
- Statistics and behavior of clinically significant extra-pulmonary vein atrial fibrillation sources: machine-learning-enhanced electrographic flow mapping in persistent atrial fibrillation.Frontiers in cardiovascular medicine · 2025Article
- Impact of Atrial Fibrillation Triggers on Long-Term Outcomes of a Second Catheter Ablation of Nonparoxysmal Atrial Fibrillation.Circulation reports · 2024Article
- Electrographic flow mapping of persistent atrial fibrillation: intra- and inter-procedure reproducibility in the absence of 'ground truth'.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Electrographic flow mapping for atrial fibrillation: theoretical basis and preliminary observations.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Review
- Rotor mechanism and its mapping in atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Review
- Mapping for nonpulmonary vein atrial fibrillation sources: The road to improved ablation outcomes.Journal of cardiovascular electrophysiology · 2023Article
- Artificial intelligence software standardizes electrogram-based ablation outcome for persistent atrial fibrillation.Journal of cardiovascular electrophysiology · 2022Article
- Safety and effectiveness of a novel dielectric mapping system: one-year, two chinese centers experiences.BMC cardiovascular disorders · 2022Article
- Convolutional Neural Networks for Mechanistic Driver Detection in Atrial Fibrillation.International journal of molecular sciences · 2022Article
- Future Directions for Mapping Atrial Fibrillation.Arrhythmia & electrophysiology review · 2022Review
- A novel approach for quantitative electrogram analysis for driver identification: Implications for ablation in persistent atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Stochastic termination of spiral wave dynamics in cardiac tissue.Frontiers in network physiology · 2022Article
- Identifying Atrial Fibrillation Mechanisms for Personalized Medicine.Journal of clinical medicine · 2021Review
- First-in-human demonstration of 18-month spatiotemporal stability of active atrial fibrillation source detected by electrographic flow mapping in persistent atrial fibrillation.HeartRhythm case reports · 2021Article
- Mapping atrial fibrillation : An overview of potential mechanisms underlying atrial fibrillation.Herz · 2021Review
- New Insights Into Understanding Rotor Versus Focal Activation in Patients With Persistent Atrial Fibrillation.JACC. Clinical electrophysiology · 2021Article
- Novel approaches to mechanism-based atrial fibrillation ablation.Cardiovascular research · 2021Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary vein isolation is insufficient to treat all patients with persistent atrial fibrillation (AF), and effective adjunctive ablation strategies are needed. Ablation of AF drivers holds promise, but current technologies to identify drivers are limited by spatial resolution. In a single-arm, first-in-human, investigator-initiated Food and Drug Administration Investigational Device Exemption study, we used a novel system for real-time, high-resolution identification of AF drivers in persistent AF.
methodsPatients with persistent or long-standing persistent AF underwent ablation using the RADAR (Real-Time Electrogram Analysis for Drivers of Atrial Fibrillation) system in conjunction with a standard electroanatomical mapping system. After pulmonary vein isolation, electrogram and spatial information was streamed to the RADAR system and analyzed to identify driver domains to target for ablation.
resultsAcross 4 centers, 64 subjects were enrolled: 73% male, age, 64.7±9.5 years; body mass index, 31.7±6.0 kg/m
conclusionsThis novel technology for panoramic mapping of AF drivers showed promising results in a persistent/long-standing persistent AF population. These data provide the scientific basis for a randomized trial. CLINICAL
trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT03263702; IDE#G170049.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.