ArticleACS nano2020
Self-Assembly of Aromatic Amino Acid Enantiomers into Supramolecular Materials of High Rigidity.
Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 146 citations in OpenAlex.
- Enhancing the Antimicrobial Potency of Self-Assembling Antibiotics by Co-Assembly-Based Aggregation Modulation.Macromolecular bioscience · 2026Article
- Engineering Robust Supramolecular Nanoassemblies from Amino-Acid Functionalized Stiff-Stilbene Amphiphiles.Small science · 2026Article
- Self-assembled metabolite-derived amyloid-like structures: implications for disease, therapeutics, and biomedical applications.Molecular biology reports · 2026Review
- Controlling Supramolecular Assembly through Peptide Chirality.ACS applied materials & interfaces · 2025Article
- Development of the Direct Deuteration Method for Amino Acids and Characterization of Deuterated Tryptophan.Bioengineering (Basel, Switzerland) · 2025Article
- Crystallization of L-Cysteine in Heavy Water Induces Intrinsic Fluorescence.Angewandte Chemie (International ed. in English) · 2025Article
- Amino Acid-Derived Supramolecular Assembly and Soft Materials.Molecules (Basel, Switzerland) · 2024Review
- A Review on the Rheological Properties of Single Amino Acids and Short Dipeptide Gels.Gels (Basel, Switzerland) · 2024Review
- 1-Naphthylacetic acid appended amino acids-based hydrogels: probing of the supramolecular catalysis of ester hydrolysis reaction.Nanoscale advances · 2024Article
- Article
- Non-thermal plasma modulated l-tyrosine self-assemblies: a potential avenue for fabrication of supramolecular self-assembled biomaterials.RSC advances · 2024Article
- Biomimetic chiral hydrogen-bonded organic-inorganic frameworks.Nature communications · 2024Article
- Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers.Bioconjugate chemistry · 2023Article
- Elucidating the Racemization Mechanism of Aliphatic and Aromatic Amino Acids by In Silico Tools.International journal of molecular sciences · 2023Article
- Enzymatic polymerization of enantiomericNature communications · 2023Article
- Unidirectional rotation of micromotors on water powered by pH-controlled disassembly of chiral molecular crystals.Nature communications · 2023Article
- Short Peptide Self-Assembly in the Martini Coarse-Grain Force Field Family.Accounts of chemical research · 2023Article
- Synthesis and Self-Assembly of Hyperbranched Multiarm Copolymer Lysozyme Conjugates Based on Light-Induced Metal-Free Atrp.Nanomaterials (Basel, Switzerland) · 2023Article
- Molecular Engineering of Rigid Hydrogels Co-assembled from Collagenous Helical Peptides Based on a Single Triplet Motif.ACS applied materials & interfaces · 2022Article
- Chiral molecular nanosilicas.Chemical science · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most natural biomolecules may exist in either of two enantiomeric forms. Although in nature, amino acid biopolymers are characterized by l-type homochirality, incorporation of d-amino acids in the design of self-assembling peptide motifs has been shown to significantly alter enzyme stability, conformation, self-assembly behavior, cytotoxicity, and even therapeutic activity. However, while functional metabolite assemblies are ubiquitous throughout nature and play numerous important roles including physiological, structural, or catalytic functions, the effect of chirality on the self-assembly nature and function of single amino acids is not yet explored. Herein, we investigated the self-assembly mechanism of amyloid-like structure formation by two aromatic amino acids, phenylalanine (Phe) and tryptophan (Trp), both previously found as extremely important for the nucleation and self-assembly of aggregation-prone peptide regions into functional structures. Employing d-enantiomers, we demonstrate the critical role that amino acid chirality plays in their self-assembly process. The kinetics and morphology of pure enantiomers is completely altered upon their coassembly, allowing to fabricate different nanostructures that are mechanically more robust. Using diverse experimental techniques, we reveal the different molecular arrangement and self-assembly mechanism of the dl-racemic mixtures that resulted in the formation of advanced supramolecular materials. This study provides a simple yet sophisticated engineering model for the fabrication of attractive materials with bionanotechnological applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.