ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020
Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- HDAC Inhibition Reshapes Splicing of Synaptic Plasticity-Related Genes and Neural Network Dynamics.Cellular and molecular neurobiology · 2026Article
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- Temporal ablation of the ciliary protein IFT88 alters normal brainwave patterns.Scientific reports · 2025Article
- Temporal Ablation of the Ciliary Protein IFT88 Alters Normal Brainwave Patterns.bioRxiv : the preprint server for biology · 2024Article
- Assessment of Fractal Synchronization during an Epileptic Seizure.Entropy (Basel, Switzerland) · 2024Article
- Entorhinal cortical Island cells regulate temporal association learning with long trace period.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy.Frontiers in behavioral neuroscience · 2021Review
- Bidirectional regulation of distinct memory domains by α5-subunit-containing GABALearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The Quest for the Hippocampal Memory Engram: From Theories to Experimental Evidence.Frontiers in behavioral neuroscience · 2020Review
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Authors and funding
4 authors.
Funding
Abstract
Memory is thought to be encoded by sparsely distributed neuronal ensembles in memory-related regions. However, it is unclear how memory-eligible neurons react during learning to encode trace fear memory and how they retrieve a memory. We implemented a fiber-optic confocal fluorescence endomicroscope to directly visualize calcium dynamics of hippocampal CA1 neurons in freely behaving mice subjected to trace fear conditioning. Here we report that the overall activity levels of CA1 neurons showed a right-skewed lognormal distribution, with a small portion of highly active neurons (termed Primed Neurons) filling the long-tail. Repetitive training induced Primed Neurons to shift from random activity to well-tuned synchronization. The emergence of activity synchronization coincided with the appearance of mouse freezing behaviors. In recall, a partial synchronization among the same subset of Primed Neurons was induced from random dynamics, which also coincided with mouse freezing behaviors. Additionally, training-induced synchronization facilitated robust calcium entry into Primed Neurons. In contrast, most CA1 neurons did not respond to tone and foot shock throughout the training and recall cycles. In conclusion, Primed Neurons are preferably recruited to encode trace fear memory and induction of activity synchronization among Primed Neurons out of random dynamics is critical for trace memory formation and retrieval.
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