ArticleEpilepsia2020
Seizures induce obstructive apnea in DBA/2J audiogenic seizure-prone mice: Lifesaving impact of tracheal implants.
Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Inflammation modifies breathing phenotype in mice with epilepsy.Journal of neuroinflammation · 2026Article
- The Crucial Interplay Between the Lungs, Brain, and Heart to Understand Epilepsy-Linked SUDEP: A Literature Review.Brain sciences · 2025Review
- Review
- Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy.Frontiers in cellular neuroscience · 2023Article
- Audiogenic epileptic DBA/2 mice strain as a model of genetic reflex seizures and SUDEP.Frontiers in neurology · 2023Review
- The role of sleep state and time of day in modulating breathing in epilepsy: implications for sudden unexpected death in epilepsy.Frontiers in neural circuits · 2022Review
- Diaphragmatic pacing for the prevention of sudden unexpected death in epilepsy.Brain communications · 2022Article
- Assessment of respiratory effort with EMG extracted from ECG recordings during prolonged breath holds: Insights into obstructive apnea and extreme physiology.Physiological reports · 2021Article
- Suppression of phrenic nerve activity as a potential predictor of imminent sudden unexpected death in epilepsy (SUDEP).Neuropharmacology · 2021Article
- The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy.Frontiers in neuroscience · 2021Review
- Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model ofFrontiers in neuroscience · 2021Article
- Causes and Effects Contributing to Sudden Death in Epilepsy and the Rationale for Prevention and Intervention.Frontiers in neurology · 2020Article
- Proposed Mechanism-Based Risk Stratification and Algorithm to Prevent Sudden Death in Epilepsy.Frontiers in neurology · 2020Review
- When Apnea Turns Terminal: When, How, Why?Epilepsy currentsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. We hypothesized that DBA/2J mice, which display lethal audiogenic seizures, would be protected from death by implanting a tracheal T-tube as a surrogate airway. In a 2 × 2 design, mice were implanted with either open or closed tracheal T-tubes and treated with either low-dose ketamine/xylazine to moderate thoracic spasm during the tonic seizure phase or no drug. Animals receiving both treatments had the highest survival rate, followed by animals receiving the open tube without ketamine/xylazine. The odds ratio for survival was >20 higher with an open T-tube (odds ratio = 24.14). The impact of open tracheal tubes indicates that the mechanism of death in DBA/2J mice involves seizure-induced upper airway obstruction until respiratory arrest. These results, our rat work, and our demonstration of inspiratory effort-based electromyographic signals and electrocardiographic abnormalities in rats and humans suggest that seizure-induced laryngospasm and obstructive apnea directly link seizure activity to respiratory arrest in these sudden death examples.
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Registered trials
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