ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Cholinergic White Matter Lesions, AD-Signature Cortical Thickness, and Change in Cognition: The Northern Manhattan Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sporadic cerebral small vessel disease and cognitive decline in healthy older adults: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Associations of Regional White Matter Hyperintensities Severity with Different Visual Rating Scales and Domain-Specific Cognitive Impairment.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Associations of cholinergic white matter hyperintensity volume with cognitive decline and incident dementia in older adults: a cohort study.BMC geriatrics · 2025Article
- Differences in cerebral structure among patients with amnestic mild cognitive impairment and patients with Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Herpes simplex virus 2 serology is associated with thinner whole-brain cortex in community-dwelling older adults.Journal of the neurological sciences · 2023Article
- Intracranial artery stenosis is associated with cortical thinning in stroke-free individuals of two longitudinal cohorts.Journal of the neurological sciences · 2023Article
- White matter and gray matter changes related to cognition in community populations.Frontiers in aging neuroscience · 2023Article
- Individual prediction and classification of cognitive impairment in patients with white matter lesions based on gray matter volume.Annals of translational medicine · 2022Article
- Vascular Cognitive Impairment (VCI).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- The Correlation Between White Matter Hyperintensity Burden and Regional Brain Volumetry in Patients With Alzheimer's Disease.Frontiers in human neuroscience · 2022Article
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9 authors.
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Abstract
backgroundHow cerebrovascular disease and neurodegeneration affect each other to impact cognition is not yet known. We aimed to test whether Alzheimer's disease-signature (AD) cortical thickness mediates the association between cholinergic white matter lesion load and change in domain-specific cognition.
methodsClinically stroke-free participants from the Northern Manhattan Study with both regional white matter hyperintensity volume (WMHV) and gray matter measurements were included (N = 894). Tract-specific WMHVs were quantified through FSL using the Johns Hopkins University white matter tract atlas. We used Freesurfer 5.1 to estimate regional cortical thickness. We fit structural equation models, including multiple indicator latent change score models, to examine associations between white matter hyperintensity volume (WMHV) in cholinergic tracts, AD-signature region cortical thickness (CT), and domain-specific cognition.
resultsOur sample (N = 894) had a mean (SD) age = 70 (9) years, years of education = 10 (5), 63% women, and 67% Hispanics/Latinos. Greater cholinergic WMHV was significantly related to worse processing speed at baseline (standardized β = -0.17, SE = 0.05, p = .001) and over time (standardized β = -0.28, SE = 0.09, p = .003), with a significant indirect effect of AD-signature region CT (baseline: standardized β = -0.02, SE = 0.01, p = .023; change: standardized β = -0.03, SE = 0.02, p = .040).
conclusionsCholinergic tract WMHV is associated with worse processing speed, both directly and indirectly through its effect on AD-signature region CT.
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