ArticleeLife2020
Comprehensive annotations of human herpesvirus 6A and 6B genomes reveal novel and conserved genomic features.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Identification of Two Competition-Defined Neutralizing Antibody Groups Targeting the HHV-6B gH/gL/gQ1/gQ2 Complex Independent of CD134 Binding.Microbiology and immunology · 2026Article
- Review
- Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA.Science advances · 2026Article
- Pan-viral ORFs discovery using massively parallel ribosome profiling.Science (New York, N.Y.) · 2025Article
- Review
- Parsing the role of NSP1 in SARS-CoV-2 infection.Cell reports · 2022Article
- Translation initiation landscape profiling reveals hidden open-reading frames required for the pathogenesis of tomato yellow leaf curl Thailand virus.The Plant cell · 2022Article
- Parsing the role of NSP1 in SARS-CoV-2 infection.bioRxiv : the preprint server for biology · 2022Article
- Overlapping genes in natural and engineered genomes.Nature reviews. Genetics · 2022Review
- Human Herpesvirus 6A Is a Risk Factor for Multiple Sclerosis.Frontiers in immunology · 2022Review
- Dynamic changes in tRNA modifications and abundance during T cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics.Cell reports · 2021Article
- Mapping the Human Herpesvirus 6B transcriptome.Journal of virology · 2021Article
- The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition.Frontiers in immunology · 2021Article
- The U94 Gene of Human Herpesvirus 6: A Narrative Review of Its Role and Potential Functions.Cells · 2020Review
- Article
- Using Direct RNA Nanopore Sequencing to Deconvolute Viral Transcriptomes.Current protocols in microbiology · 2020Article
- Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication.PLoS pathogens · 2020Article
- Herpesviral Latency-Common Themes.Pathogens (Basel, Switzerland) · 2020Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the majority of the human population. They encompass large genomes and our understanding of their protein coding potential is far from complete. Here, we employ ribosome-profiling and systematic transcript-analysis to experimentally define HHV-6 translation products. We identify hundreds of new open reading frames (ORFs), including upstream ORFs (uORFs) and internal ORFs (iORFs), generating a complete unbiased atlas of HHV-6 proteome. By integrating systematic data from the prototypic betaherpesvirus, human cytomegalovirus, we uncover numerous uORFs and iORFs conserved across betaherpesviruses and we show uORFs are enriched in late viral genes. We identified three highly abundant HHV-6 encoded long non-coding RNAs, one of which generates a non-polyadenylated stable intron appearing to be a conserved feature of betaherpesviruses. Overall, our work reveals the complexity of HHV-6 genomes and highlights novel features conserved between betaherpesviruses, providing a rich resource for future functional studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.