ArticleProceedings of the National Academy of Sciences of the United States of America1988
Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 33 citations in OpenAlex.
- TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems.Journal of immunological methods · 2015Article
- Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells.PloS one · 2009Article
- Article
- Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes.Oncogene · 2000Article
- Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.Molecular and cellular biology · 1992Article
- A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.The EMBO journal · 1991Article
- Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer.Molecular and cellular biology · 1991Article
- An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.The EMBO journal · 1990Article
- Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Primary cultures and established cell lines derived from human T-cell leukemias were analyzed for genomic rearrangements in the region 3' of the MYC locus. A T-cell leukemia line, HUT 78, whose 3' MYC region is rearranged, carries a chromosome t(2;8) juxtaposition; i.e., a locus derived from chromosome region 2q34 is attached to the 3' end of one MYC allele. The t(2;8) rearrangement in the HUT 78 cell line results in expression of a fused transcript encompassing the MYC gene and a locus designated TCL4 (T-cell leukemia/lymphoma 4), which normally resides on chromosome 2. The steady-state level of MYC-TCL4 fusion transcripts in HUT 78 cells is significantly higher than the MYC RNA level found in several other B- and T-cell lines. The production of fused MYC-TCL4 transcripts in a leukemic cell line raises the possibility that other B- and T-cell leukemias may express MYC fusion transcripts as an integral step in their pathogenesis.
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