ArticleGut microbes2020
Prospective study reveals a microbiome signature that predicts the occurrence of post-operative enterocolitis in Hirschsprung disease (HSCR) patients.
Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Machine learning in the diagnosis of Hirschsprung disease: a systematic review and meta-analysis.Pediatric surgery international · 2026Pooled it
- Age and seasonality in Hirschsprung-associated enterocolitis risk: a longitudinal cohort study.Pediatric surgery international · 2026Article
- Longitudinal analysis of gut microbiota dysbiosis and bacterial signatures predictive of postoperative enterocolitis in children with Hirschsprung disease.Clinical and experimental pediatrics · 2026Article
- Post-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.Journal of clinical medicine · 2026Review
- Precision minimally invasive strategy for Hirschsprung's disease: from anatomical resection to whole-cycle functional management-a review.Frontiers in pediatrics · 2026Review
- Preoperative gut microbial and metabolic signatures associated with postoperative Hirschsprung-associated enterocolitis in short-segment Hirschsprung disease.Frontiers in microbiology · 2026Article
- Epidemiology and Surgical Management of Hirschsprung's Disease in France: A 12-Year Retrospective Analysis (2012-2023).Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Complete Genome and Characterization Analysis of aMicroorganisms · 2025Article
- Risk factors and nomogram model for short-term postoperative complications in patients with hirschsprung disease.BMC medical informatics and decision making · 2025Article
- Associations between feeding patterns and clinical outcomes of Hirschsprung's disease after surgery: propensity score matching approach.Frontiers in nutrition · 2025Article
- Risk factors and simple scoring system for predicting postoperative nutritional status of Hirschsprung's disease.Frontiers in nutrition · 2024Article
- A unicentric cross-sectional observational study on chronic intestinal inflammation in total colonic aganglionosis: beware of an underestimated condition.Orphanet journal of rare diseases · 2023Observational
- Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis.International journal of molecular sciences · 2023Review
- Prognostic factors of postoperative Hirschsprung-associated enterocolitis: a cohort study.Pediatric surgery international · 2023Article
- Effect of live combined Bifidobacterium and Lactobacillus tablets combined with Soave radical operation on postoperative intestinal flora and immune function in children with Hirschsprung disease.American journal of translational research · 2023Article
- Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study.Frontiers in surgery · 2023Article
- Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway.Cell death discovery · 2022Article
- Article
- Different Fecal Microbiota in Hirschsprung's Patients With and Without Associated Enterocolitis.Frontiers in microbiology · 2022Article
- Pathways and microbiome modifications related to surgery and enterocolitis in Hirschsprung disease.Pediatric surgery international · 2022Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hirschsprung disease (HSCR) is a birth defect with an approximate incidence of 1/5,000 live births, and up to one-third of HSCR patients develop Hirschsprung-associated enterocolitis (HAEC), the leading cause of HSCR-related death. Very little is known about the pathogenesis, prevention, and early diagnosis of HAEC. Here, we used a prospective study to investigate the enteric microbiome composition at the time of surgery as a predictor for developing postoperative HAEC. We identified a microbiome signature containing 21 operational taxonomic units (OTUs) that can potentially predict postoperative HAEC with ~85% accuracy. Furthermore, we identified exclusive breastfeeding as a novel protective factor for total HAEC (i.e., preoperative and postoperative HAEC combined). In addition, we discovered that breastfeeding was associated with a lowered risk for HAEC potentially mediated by modulating the gut microbiome composition characterized by a lower abundance of Gram-negative bacteria and lower LPS concentrations. In conclusion, modulating the gut microbiome by encouraging breastfeeding might prevent HAEC progression in HSCR patients.
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Registered trials
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