ArticleProceedings of the National Academy of Sciences of the United States of America1988
Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 150 citations in OpenAlex.
- Pregnancy-Associated Glycoproteins Identification in Skopelos Goat Milk by Means of Mass Spectrometry.Veterinary sciences · 2025Article
- An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Highlighting the Role of Obesity and Insulin Resistance in Type 1 Diabetes and Its Associated Cardiometabolic Complications.Current obesity reports · 2022Review
- Megakaryocyte TGFβ1 partitions erythropoiesis into immature progenitor/stem cells and maturing precursors.Blood · 2020Article
- Systemic Activation of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder.International journal of molecular sciences · 2018Review
- Where Does Lenalidomide Fit in Non-del(5q) MDS?Current hematologic malignancy reports · 2015Review
- Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures.Journal of cell science · 2015Article
- Inhibin at 90: from discovery to clinical application, a historical review.Endocrine reviews · 2014Review
- Triiodothyronine suppresses activin-induced differentiation of erythroleukemia K562 cells under hypoxic conditions.Molecular and cellular biochemistry · 2014Article
- An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.Nature medicine · 2014Article
- Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.Nature medicine · 2014Article
- Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix (ECM) composition and impairing matrix vesicle (MV) production.Molecular & cellular proteomics : MCP · 2013Article
- Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin.Molecular and cellular endocrinology · 2009Review
- Interleukin-1 beta enhances and interferon-gamma suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts.Clinical and experimental immunology · 2001Article
- Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells.Oncogene · 2001Article
- Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies.Clinical and experimental immunology · 1998Article
- Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.Molecular and cellular biology · 1997Article
- Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid.Immunology · 1996Article
- Activin A/erythroid differentiation factor is induced during human monocyte activation.The Journal of experimental medicine · 1992Article
- Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells.The Journal of clinical investigation · 1992Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Activin and inhibin are biomolecules that, respectively, enhance and suppress the release of follicle-stimulating hormone from pituitary cells in vitro. Purified recombinant human (rhu) activin A and inhibin A were assessed for their effects on colony formation in vitro by human multipotential (CFU-GEMM), erythroid (BFU-E), and granulocyte-macrophage (CFU-GM) progenitor cells. It was found that (i) rhu-activin A enhances colony formation by normal bone marrow erythroid and multipotential progenitor cells; (ii) purified rhu-inhibin A decreases activin, but not rhu-interleukin 3, rhu-granulocyte-macrophage colony-stimulating factor, or rhu-interleukin 4, enhancement of erythropoietin-stimulated colony formation by erythroid and multipotential progenitor cells; (iii) modulatory actions of rhu-activin and rhu-inhibin are mediated through monocytes and T lymphocytes within the marrow; (iv) actions are apparent in the absence or presence of serum; and (v) rhu-activin and rhu-inhibin have no effect on colony formation by granulocyte-macrophage progenitor cells. This defines an indirect mode of action and a specificity for activin and inhibin on multipotential and erythroid progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.