ArticleProceedings of the National Academy of Sciences of the United States of America1988
Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 184 citations in OpenAlex.
- The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein.Scientific reports · 2019Article
- MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma.Oral oncology · 2019Article
- MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.PloS one · 2015Article
- Mice over-expressing human erythropoietin indicate that erythropoietin enhances expression of its receptor via up-regulated Gata1 and Tal1.Haematologica · 2014Article
- ESI mass spectrometric exploration of selective recognition of G-quadruplex in c-myb oncogene promoter using a novel flexible cyclic polyamide.Journal of the American Society for Mass Spectrometry · 2014Article
- α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.The Journal of biological chemistry · 2013Article
- Batf promotes growth arrest and terminal differentiation of mouse myeloid leukemia cells.Molecular cancer research : MCR · 2011Article
- A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.Nucleic acids research · 2008Article
- Article
- Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Oncogene · 2006Article
- Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.Molecular and cellular biology · 2003Article
- A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state.Oncogene · 2002Article
- Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia.Journal of virology · 2001Article
- Review
- Article
- c-Myb is critical for murine colon development.Oncogene · 1999Article
- Fli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation.Molecular and cellular biology · 1999Article
- Review
- Transformation by v-Myb.Oncogene · 1999Review
- c-Myb is essential for early T cell development.Genes & development · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of nuclear protooncogenes during erythroid cell differentiation was examined by transfecting exogenous c-fos and c-myb genes into mouse erythroleukemia cells, which can be induced to differentiate either with erythropoietin (Epo) or dimethyl sulfoxide. Expression of exogenous c-myb or c-fos oncogene completely inhibited Epo-induced erythroid differentiation but only partially inhibited dimethyl sulfoxide-induced differentiation. Normally Epo-induced differentiation leads to a drastic decline of c-myb mRNA levels and an increase of c-myc transcripts in the early stage of differentiation. Cells expressing exogenous c-fos gene, however, maintained high levels of c-myb mRNA after Epo treatment. This high level of c-myb transcripts was found to be due to block of transcription shutoff (or transcriptional activation) rather than to mRNA stabilization. It is concluded that the down-regulation of endogenous c-myb gene expression is a prerequisite for commitment of Epo-induced erythroid differentiation and that expression of c-myb gene may be indirectly regulated by c-fos gene product. We also concluded that early down-regulation of c-myc gene expression is not essential for erythroid differentiation and that gene regulation of chemically induced erythroid differentiation may differ from that of Epo-induced differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.