ArticleProceedings of the National Academy of Sciences of the United States of America1988
Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 94 citations in OpenAlex.
- Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription.Cells · 2020Review
- Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function.JCI insight · 2018Article
- A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Recruitment of cAMP-response element-binding protein and histone deacetylase has opposite effects on glucocorticoid receptor gene transcription.The Journal of biological chemistry · 2010Article
- Gene expression profile of androgen modulated genes in the murine fetal developing lung.Reproductive biology and endocrinology : RB&E · 2010Article
- TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.The Journal of biological chemistry · 2009Article
- Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Human type 2 17 beta-hydroxysteroid dehydrogenase mRNA and protein distribution in placental villi at mid and term pregnancy.Reproductive biology and endocrinology : RB&E · 2007Article
- Sexually dimorphic gene expression that overlaps maturation of type II pneumonocytes in fetal mouse lungs.Reproductive biology and endocrinology : RB&E · 2006Article
- Tbx19, a tissue-selective regulator of POMC gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- Insulin-secreting non-islet cells are resistant to autoimmune destruction.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Regulation of corticotropin releasing hormone receptor type 1 messenger RNA level in Y-79 retinoblastoma cells: potential implications for human stress response and immune/inflammatory reaction.Mediators of inflammation · 1996Article
- Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene.Molecular and cellular biology · 1993Article
- Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements.Molecular and cellular biology · 1991Article
- Pituitary-like proopiomelanocortin transcripts in human Leydig cell tumors.The Journal of clinical investigation · 1990Article
- A novel transcriptional activator (PO-B) binds between the TATA box and cap site of the pro-opiomelanocortin gene.Nucleic acids research · 1990Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The product of a single gene encoding proopiomelanocortin (POMC) is differentially processed to produce corticotropin and alpha-melanotropin in anterior and intermediate pituitary cells, respectively. Hormonal control of POMC gene transcription and of corticotropin or alpha-melanotropin release is also tissue-specific; for example, glucocorticoids specifically inhibit anterior but not intermediate pituitary POMC transcription. Outside the pituitary gland, very low levels of POMC mRNAs are present in brain, testes, ovaries, and placenta. We have used transgenic mice to identify POMC 5' flanking sequences that are sufficient for tissue-specific expression and glucocorticoid regulation in anterior and intermediate pituitary cells. Three lines of transgenic mice were established, each carrying 50-75 copies (per cell) of a chimeric rPOMCneo gene constituted of rat POMC promoter sequences and of bacterial neomycin-resistance coding sequence. High levels of rPOMCneo transcripts were detected in pituitaries of mice from all three lineages. In situ hybridization revealed that the ratio of intermediate to anterior pituitary transcripts was similar for the transgene and endogenous POMC mRNA. rPOMCneo transcripts were not detected in any other tissue except at very low levels in the testes in two transgenic lines. Endogenous mouse POMC mRNA increased in response to depletion of plasma glucocorticoids (adrenalectomy) and decreased after glucocorticoid treatment; rPOMCneo transcripts were altered to the same extent by these treatments in all three lines. Intermediate pituitary and testicular rPOMCneo transgene expression was not altered by these treatments. Thus, no more than 769 base pairs of the rat POMC promoter are required for pituitary-specific expression and for specific glucocorticoid inhibition of the POMC gene in the anterior pituitary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.