ArticleAngewandte Chemie (International ed. in English)2020
Amphiphilic Polyphenylene Dendron Conjugates for Surface Remodeling of Adenovirus 5.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity.Engineering (Beijing, China) · 2023Article
- Nanographenes and Graphene Nanoribbons as Multitalents of Present and Future Materials Science.Journal of the American Chemical Society · 2022Review
- Photostable polymorphic organic cages for targeted live cell imaging.Chemical science · 2022Article
- Synthesis of Giant Dendritic Polyphenylenes with 366 and 546 Carbon Atoms and Their High-vacuum Electrospray Deposition.Chemistry, an Asian journal · 2022Article
- Polymeric Systems for Cancer Immunotherapy: A Review.Frontiers in immunology · 2022Review
- Reversing Aβ Fibrillation and Inhibiting Aβ Primary Neuronal Cell Toxicity Using Amphiphilic Polyphenylene Dendrons.Advanced healthcare materials · 2022Article
- Blood Compatibility of Amphiphilic Phosphorous Dendrons-Prospective Drug Nanocarriers.Biomedicines · 2021Article
- Article
- Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity.Pharmaceutics · 2021Review
- Amphiphilic Polyphenylene Dendron Conjugates for Surface Remodeling of Adenovirus 5.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphiphilic surface groups play an important role in many biological processes. The synthesis of amphiphilic polyphenylene dendrimer branches (dendrons), providing alternating hydrophilic and lipophilic surface groups and one reactive ethynyl group at the core is reported. The amphiphilic surface groups serve as biorecognition units that bind to the surface of adenovirus 5 (Ad5), which is a common vector in gene therapy. The Ad5/dendron complexes showed high gene transduction efficiencies in coxsackie-adenovirus receptor (CAR)-negative cells. Moreover, the dendrons offer incorporation of new functions at the dendron core by in situ post-modifications, even when bound to the Ad5 surface. Surfaces coated with these dendrons were analyzed for their blood-protein binding capacity, which is essential to predict their performance in the blood stream. A new platform for introducing bioactive groups to the Ad5 surface without chemically modifying the virus particles is provided.
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Registered trials
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