ArticleAngewandte Chemie (International ed. in English)2020
A Phototheranostic Strategy to Continuously Deliver Singlet Oxygen in the Dark and Hypoxic Tumor Microenvironment.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 196 citations in OpenAlex.
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- Synergistic photodynamic and chemodynamic therapy using hypoxia-adaptive Ce6@Co nanoparticles for enhanced tumor suppression.International journal of pharmaceutics: X · 2025Article
- A pH-Sensitive Nanosized Covalent-Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Nanotherapeutic Agent for Synergistic Tumor Therapy: Co-Activation of Photochemical-Biological Effects.Angewandte Chemie (International ed. in English) · 2025Article
- Oxygen tension regulating nanoformulation for the improved photodynamic therapy of hypoxic tumors.Materials today. Bio · 2025Article
- Orthogonally conjugated phthalocyanine-porphyrin oligomer for NIR photothermal-photodynamic antibacterial treatment.Communications chemistry · 2025Article
- Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma.Materials today. Bio · 2025Article
- Acid-responsive singlet oxygen nanodepots.Chemical science · 2025Article
- Molecular Engineering of a Tumor-Targeting Thione-Derived Diketopyrrolopyrrole Photosensitizer to Attain NIR Excitation Over 850 nm for Efficient Dual Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Confined semiconducting polymers with boosted NIR light-triggered HChemical science · 2024Article
- pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy.Bioactive materials · 2024Article
- Theranostics - a sure cure for cancer after 100 years?Theranostics · 2024Review
- Modularized supramolecular assemblies for hypoxia-activatable fluorescent visualization and image-guided theranostics.Theranostics · 2024Article
- The Application of Drugs and Nano-Therapies Targeting Immune Cells in Hypoxic Inflammation.International journal of nanomedicine · 2024Review
- Catalyzing Generation and Stabilization of Oxygen Vacancies on CeOAdvanced healthcare materials · 2023Article
- The Role of Integrins for Mediating Nanodrugs to Improve Performance in Tumor Diagnosis and Treatment.Nanomaterials (Basel, Switzerland) · 2023Review
- Recent Advances of Diketopyrrolopyrrole Derivatives in Cancer Therapy and Imaging Applications.Molecules (Basel, Switzerland) · 2023Review
- Multifunctional Nanoplatform Based on Sunitinib for Synergistic Phototherapy and Molecular Targeted Therapy of Hepatocellular Carcinoma.Micromachines · 2023Article
- Editorial: Synthesis of novel photosensitizers for cancer theranostics.Frontiers in chemistry · 2023Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT-induced hypoxia, providing singlet oxygen from stored chemical energy may enhance the cell-killing effect and boost the therapeutic effect. Herein, we present a phototheranostic (DPPTPE@PEG-Py NPs) prepared by using a 2-pyridone-based diblock polymer (PEG-Py) to encapsulate a semiconducting, heavy-atom-free pyrrolopyrrolidone-tetraphenylethylene (DPPTPE) with high singlet-oxygen-generation ability both in dichloromethane and water. The PEG-Py can trap the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.