ArticleAngewandte Chemie (International ed. in English)2020
Stable Prenucleation Calcium Carbonate Clusters Define Liquid-Liquid Phase Separation.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Spectroscopic Evidence in Optical Absorption for the Formation and Transformation of Prenucleation Clusters of CdS Quantum Dots.ACS central science · 2026Article
- Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters.Analytical chemistry · 2025Article
- Influence of Nanobubbles on the Early Stages of Calcium Carbonate Formation.Crystal growth & design · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Impact of MgProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-Stoichiometric Amorphous Calcium Carbonate Forms in Macromolecular Condensates via Interphase Diffusion.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- From Ions to Crystals: A Comprehensive View of the Non-Classical Nucleation of Calcium Sulfate.Angewandte Chemie (International ed. in English) · 2024Article
- Nanostructured Surfaces Enhance Nucleation Rate of Calcium Carbonate.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Branched Polymeric Prenucleation Assemblies Initiate Calcium Phosphate Precipitation.Journal of the American Chemical Society · 2024Article
- Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization.Communications chemistry · 2024Article
- Amorphous aggregates with a very wide size distribution play a central role in crystal nucleation.Chemical science · 2024Article
- Kinetic and Thermodynamic Interplay of Polymer-Mediated Liquid-Liquid Phase Separation for Poorly Water-Soluble Drugs.Molecular pharmaceutics · 2024Article
- Prenucleation Cluster Pathway is Inconsistent with CaCOCrystal growth & design · 2024Article
- Redefined ion association constants have consequences for calcium phosphate nucleation and biomineralization.Nature communications · 2024Article
- Calcium Carbonate Prenucleation Cluster Pathway Observed via In Situ Small-Angle X-ray Scattering.The journal of physical chemistry letters · 2023Article
- Secondary Structure of DNA Aptamer Influences Biomimetic Mineralization of Calcium Carbonate.ACS applied materials & interfaces · 2023Article
- Biomimetic Mineralized Hydrophilic Polyurethane Primers for Inducing Dentin Tubule Fillings.Polymers · 2022Article
- The Role of Intrinsically Disordered Proteins in Liquid-Liquid Phase Separation during Calcium Carbonate Biomineralization.Biomolecules · 2022Review
- Role of Mass Transport in the Deposition, Growth, and Transformation of Calcium Carbonate on Surfaces at High Supersaturation.Crystal growth & design · 2022Article
- Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization.Frontiers in chemistry · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Liquid-liquid phase separation (LLPS) is an intermediate step during the precipitation of calcium carbonate, and is assumed to play a key role in biomineralization processes. Here, we have developed a model where ion association thermodynamics in homogeneous phases determine the liquid-liquid miscibility gap of the aqueous calcium carbonate system, verified experimentally using potentiometric titrations, and kinetic studies based on stopped-flow ATR-FTIR spectroscopy. The proposed mechanism explains the variable solubilities of solid amorphous calcium carbonates, reconciling previously inconsistent literature values. Accounting for liquid-liquid amorphous polymorphism, the model also provides clues to the mechanism of polymorph selection. It is general and should be tested for systems other than calcium carbonate to provide a new perspective on the physical chemistry of LLPS mechanisms based on stable prenucleation clusters rather than un-/metastable fluctuations in biomineralization, and beyond.
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