ArticleJournal of magnetic resonance imaging : JMRI2020
Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers.
Article in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Topology Outweighs Stiffness: Self-Reinforced Cell Mechanotransduction via Multiaxial Curvature Engineering of Ultrasoft Hydrogels.ACS nano · 2026Article
- Quantitative pancreatic MRI in diabetes mellitus: current advances and future directions.Frontiers in endocrinology · 2026Review
- Evaluation of pancreatic iodine uptake and related influential factors in multiphase dual-energy CT.European radiology · 2024Article
- Cross-sectional imaging of the pancreas in diabetes.Abdominal radiology (New York) · 2024Review
- Imaging evaluation of the pancreas in diabetic patients.Abdominal radiology (New York) · 2022Review
- Multi-frequency magnetic resonance elastography of the pancreas: measurement reproducibility and variance among healthy volunteers.Gastroenterology report · 2022Article
- Quantitative Magnetic Resonance Imaging of the Pancreas of Individuals With Diabetes.Frontiers in endocrinology · 2020Review
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8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundLarge-scale normative studies of pancreatic stiffness and potential influences have yet to be pursued via magnetic resonance elastography (MRE). PURPOSE: To determine normative MRE-based pancreatic stiffness values and to examine related influential factors. STUDY TYPE: Prospective. SUBJECTS: In all, 361 volunteers (men, 199; women, 162) with a median age of 54.0 years and a median body mass index (BMI) of 22.86 kg/m FIELD STRENGTH/SEQUENCE: Each volunteer underwent 3.0T pancreatic MRI at a frequency of 40 Hz. ASSESSMENT: Pancreatic stiffness values, pancreatic width and volume, waist circumference, and wave distance were measured in all subjects. STATISTICAL TESTS: Multiple linear regression analyses were performed to determine variables that influence MRE-determined stiffness.
resultsThe mean pancreatic stiffness in all volunteers was 1.20 ± 0.16 kPa. Stiffness levels in positive control volunteers proved significantly greater than levels in healthy volunteers (1.29 ± 0.17 kPa vs. 1.14 ± 0.13 kPa; P < 0.001). In multiple linear regression analysis, sex (P = 0.004), BMI (P < 0.001), pancreatic width (P = 0.005), smoking (P < 0.001), alcohol abuse (P < 0.001), and DM (P = 0.001) emerged as significant independent factors impacting pancreatic stiffness. Smoking, alcohol abuse, DM, and wide pancreas were associated with greater pancreatic stiffness (coefficients = 0.202, 0.183, 0.149, and 0.160, respectively), while reduced pancreatic stiffness corresponded with female sex and larger BMI (coefficient = -0.155 and -0.192, respectively). DATA
conclusionMRE-based pancreatic stiffness values are impacted by sex, BMI, pancreatic width, smoking, alcohol abuse, and DM. Reference values are essential for future clinical studies. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;52:448-458.
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