Evidence map›Paper›PMID 31943410›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Synthesis and Biological Characterization of Monomeric and Tetrameric RGD-Cryptophycin Conjugates.

Adina Borbély, Fabien Thoreau, Eduard Figueras, Malika Kadri, Jean-Luc Coll, Didier Boturyn, Norbert Sewald

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Chemistry of Phytoplankton.Chemical reviews · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Adina BorbélyOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.ORCID http://orcid.org/0000-0002-5506-6555
Fabien ThoreauCNRS, Department of Molecular Chemistry, University Grenoble Alpes, UMR 5250, 38000, Grenoble, France.
Eduard FiguerasOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.ORCID http://orcid.org/0000-0002-1853-9974
Malika KadriInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209-UMR CNRS 5309, 38700, Grenoble, France.
Jean-Luc CollInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209-UMR CNRS 5309, 38700, Grenoble, France.ORCID http://orcid.org/0000-0002-2453-3552
Didier BoturynCNRS, Department of Molecular Chemistry, University Grenoble Alpes, UMR 5250, 38000, Grenoble, France.ORCID http://orcid.org/0000-0003-2530-0299
Norbert SewaldOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.ORCID http://orcid.org/0000-0002-0309-2655
Centre National de la Recherche Scientifique · FRBielefeld University · DE

Funding

H2020 Marie Skłodowska-Curie Actions 642004
6 · The paper itself

Abstract

The effective delivery of cytotoxic agents to tumor cells is a key challenge in anticancer therapy. Multivalent integrinspecific ligands are considered a promising tool to increase the binding affinity, selectivity, and internalization efficiency of small-molecule drug conjugates. Herein, we report the synthesis and biological evaluation of a multimeric conjugate containing the high-affinity integrin α

Indexed as

Cell Line, TumorDepsipeptidesDrug CarriersDrug LiberationHumansIntegrin alphaVbeta3Molecular Targeted TherapyPeptides, CycliccryptophycinDepsipeptidesDrug CarriersIntegrin alphaVbeta3Peptides, CyclicRAFT-RGDantitumor agentsdrug deliveryintegrinsmultivalencysmall-molecule drug conjugates

Identifiers

PMID31943410
PMCPMC7064988
OpenAlexW2999030851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.