Evidence map›Paper›PMID 31943142›Full record

ReviewBritish journal of pharmacology2020

Chronic inflammatory diseases, myocardial function and cardioprotection.

Antigone Lazou, Ignatios Ikonomidis, Monika Bartekova, Theodora Benedek, George Makavos, Dimitra Palioura, Hector Cabrera Fuentes, Ioanna Andreadou

Abstract readReview
In one paragraph

Review in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Clinical Risk Predictors for Abnormal Left Ventricular and Atrial Function in Lupus Erythematosus.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Bioactive Compounds inPlants (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antigone LazouSchool of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-7889-9648
Ignatios IkonomidisSecond Cardiology Department, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Monika BartekovaInstitute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia.
Theodora BenedekClinic of Cardiology, Cardiac Critical Care Unit, University of Medicine and Pharmacy, Târgu Mureş, Romania.
George MakavosSecond Cardiology Department, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitra PaliouraSchool of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Hector Cabrera FuentesSingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme and Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.ORCID 0000-0002-8502-7098
Ioanna AndreadouLaboratory of Pharmacology, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

Funding

European Cooperation in Science and TechnologyKazan Federal UniversitySingapore Heart Foundation SHF/FG657P/2017Von Behring-Röntgen-FoundationVon-Behring-Röntgen-Stiftung
6 · The paper itself

Abstract

The association between chronic inflammatory diseases (CIDs) and increased cardiovascular (CV) risk is well documented and can be a most threatening complication in these patients. However, the pathogenetic mechanisms underlying increased CV risk remain elusive, especially in their cellular and biochemical pathways. Using animal models to understand mechanisms underlying cardiac involvement are limited. Additionally, treatments may influence cardiovascular events through different outcomes. Some drugs used to treat CIDs can negatively affect cardiac function by a direct toxicity, whereas others may protect the myocardium. In the present article, we focus on the cardiac manifestations and risk factors, the pathogenetic mechanisms, and the effect of treatments on myocardial function and cardioprotection for five common worldwide CIDs (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, psoriasis and inflammatory bowel disease). We also give recommendations in order to evaluate common targets between CID and CV disease (CVD) and to design therapies to alleviate CID-related CVD. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc.

Indexed as

CardiomyopathiesCardiovascular DiseasesAnimalsChronic DiseaseHumansMyocardium

Identifiers

PMID31943142
PMCPMC7680008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.