Evidence map›Paper›PMID 31943072›Full record

SynthesisNutrition reviews2020

Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.

Marie C Conway, Emeir M McSorley, Maria S Mulhern, J J Strain, Edwin van Wijngaarden, Alison J Yeates

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Marie C ConwayNutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland. E. van Wijngaarden is with the School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Emeir M McSorleyNutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland. E. van Wijngaarden is with the School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Maria S MulhernNutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland. E. van Wijngaarden is with the School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
J J StrainNutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland. E. van Wijngaarden is with the School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Edwin van WijngaardenNutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland. E. van Wijngaarden is with the School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Alison J YeatesNutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland. E. van Wijngaarden is with the School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
University of Ulster · GBUniversity of Rochester · US

Funding

TOXICITY OF METHYL MERCURY IN A FISH EATING POPULATIONR01ES010219 · NIEHS · UNIVERSITY OF ROCHESTER · PI VAN WIJNGAARDEN, EDWIN · 2000 to 2019
$11.8M
NIEHS NIH HHS R01 ES010219
6 · The paper itself

Abstract

contextPolyunsaturated fatty acids (PUFA) are important during pregnancy for fetal development and child health outcomes. The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and α-linolenic acid.

objectiveThe current review discusses the influence of FADS genotype on PUFA status of pregnant women, breast milk, and children, and also how FADS may influence child health outcomes. DATA SOURCES: The Ovid Medline, Scopus, Embase, Cochrane Library, CINAHL Plus, PubMed and Web of Science databases were searched from their inception to September 2018. DATA EXTRACTION: Eligible studies reported FADS genotype and blood concentrations of PUFA during pregnancy, in childhood, breast milk concentrations of PUFA or child health outcomes. DATA ANALYSIS: In pregnant and lactating women, minor allele carriers have higher concentrations of linoleic acid and α-linolenic acid, and lower concentrations of arachidonic acid, in blood and breast milk, respectively. In children, FADS genotype influences PUFA status in the same manner and may impact child outcomes such as cognition and allergies; however, the direction of effects for the evidence to date is not consistent.

conclusionFurther studies are needed to further investigate associations between FADS and outcomes, as well as the diet-gene interaction.

Indexed as

AllelesChild HealthAdolescentAdultArachidonic AcidChildChild, PreschoolDocosahexaenoic AcidsFatty Acid DesaturasesFatty Acids, UnsaturatedFemaleHumansInfantLinoleic AcidMilk, HumanPolymorphism, Single NucleotideArachidonic AcidDocosahexaenoic AcidsFatty Acid DesaturasesFatty Acids, UnsaturatedLinoleic Acidchild outcomesFADSfatty acid desaturasepolyunsaturated fatty acidspregnancyPUFA

Identifiers

PMID31943072
PMCPMC7868964
OpenAlexW2998827413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.