ArticleJournal of experimental botany2020
An allelic variant of GAME9 determines its binding capacity with the GAME17 promoter in the regulation of steroidal glycoalkaloid biosynthesis in tomato.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Physiological and Molecular Mechanisms of Light-Induced Greening in Potatoes: A Path to Food Safety.Foods (Basel, Switzerland) · 2025Review
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network.Science advances · 2025Article
- Potato steroidal glycoalkaloids: properties, biosynthesis, regulation and genetic manipulation.Molecular horticulture · 2024Review
- A distal enhancer guides the negative selection of toxic glycoalkaloids during tomato domestication.Nature communications · 2024Article
- Current Advances in the Biosynthesis, Metabolism, and Transcriptional Regulation of α-Tomatine in Tomato.Plants (Basel, Switzerland) · 2023Review
- Targeted approaches to improve tomato fruit taste.Horticulture research · 2023Article
- Metabolomic and transcriptomic analyses identify external conditions and key genes underlying high levels of toxic glycoalkaloids in tubers of stress-sensitive potato cultivars.Frontiers in plant science · 2023Article
- Interplay of transcription factors orchestrating the biosynthesis of plant alkaloids.3 Biotech · 2022Review
- Genetic divergence in transcriptional regulators of defense metabolism: insight into plant domestication and improvement.Plant molecular biology · 2022Review
- Steroidal alkaloid biosynthesis is coordinately regulated and differs among tomatoes in the red-fruited clade.The plant genome · 2022Article
- Multi-Omics Analysis Reveals ThatFrontiers in plant science · 2022Article
- Antioxidants in Potatoes: A Functional View on One of the Major Food Crops Worldwide.Molecules (Basel, Switzerland) · 2021Review
- Bitter and sweet make tomato hard to (b)eat.The New phytologist · 2021Article
- Plant Metabolic Gene Clusters: Evolution, Organization, and Their Applications in Synthetic Biology.Frontiers in plant science · 2021Review
- Special Issue on "Fruit Metabolism and Metabolomics".Metabolites · 2020Article
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14 authors.
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Abstract
Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules found in the family Solanaceae. SGA content varies among different plant species and varieties. However, the genetic mechanisms regulating SGA content remain unclear. Here, we demonstrate that genetic variation in GLYCOALKALOID METABOLISM 9 (GAME9) is responsible for the variation in SGA content in tomato (Solanum lycopersicum). During a sequential analysis we found a 1 bp substitution in the AP2/ERF binding domain of GAME9. The 1 bp substitution in GAME9 was significantly associated with high SGA content and determined the binding capacity of GAME9 with the promoter of GAME17, a core SGA biosynthesis gene. The high-SGA GAME9 allele is mainly present in S. pimpinellifolium and S. lycopersicum var. cerasiforme populations and encodes a protein that can bind the GAME17 promoter. In contrast, the low-SGA GAME9 allele is mainly present in the big-fruited varieties of S. lycopersicum and encodes a protein that shows weak binding to the GAME17 promoter. Our findings provide new insight into the regulation of SGA biosynthesis and the factors that affect the accumulation of SGA in tomato.
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