Evidence map›Paper›PMID 31942754›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2020

Association between Retinal Vascular Geometric Changes and Cognitive Impairment: A Systematic Review and Meta-Analysis.

Huiqun Wu, Chendong Wang, Cong Chen, Xiaotao Xu, Yi Zhu, Aimin Sang, Kui Jiang, Jiancheng Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huiqun Wu *Department of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0001-5837-6199
Chendong Wang *Department of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0002-8334-0232
Cong ChenDepartment of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0002-2158-1217
Xiaotao XuDepartment of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0001-6071-2147
Yi ZhuDepartment of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0003-0507-7042
Aimin SangDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, China. sangam@ntu.edu.cn.ORCID https://orcid.org/0000-0002-9669-403X
Kui JiangDepartment of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0002-0327-7385
Jiancheng DongDepartment of Medical Informatics, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0002-9646-2853

Funding

National Key R&D Program of China 2018YFC1314900National Key R&D Program of China 2018YFC1314902
6 · The paper itself

Abstract

background and purposePrevious studies have explored the association between retinal vascular changes and cognitive impairment. The retinal vasculature shares some characteristics with the cerebral vasculature, and quantitative changes in it could indicate cognitive impairment. Hence, a comprehensive meta-analysis was performed to clarify the potential relationship between retinal vascular geometric changes and cognitive impairment.

methodsRelevant databases were scrupulously and systematically searched for retinal vascular geometric changes including caliber, tortuosity, and fractal dimension (FD), and for cognitive impairment. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of included studies. RevMan was used to perform the meta-analysis and detect publication bias. Sensitivity analyses were also performed.

resultsFive studies that involved 2,343 subjects were finally included in the meta-analysis. The results showed that there was no significant association between central retinal artery equivalents (Z=1.17) or central retinal venular equivalents (Z=1.74) and cognitive impairment (both

conclusionsA smaller retinal microvascular FD might be associated with cognitive impairment. Further large-sample and well-controlled original studies are required to confirm the present findings.

Indexed as

cognitive impairmentmeta-analysisretinaretinal vessels

Identifiers

PMID31942754
PMCPMC6974814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.