Evidence map›Paper›PMID 31942750›Full record

ArticleThrombosis and haemostasis2020

Reduced Plasma Magnesium Levels in Type-1 Diabetes Associate with Prothrombotic Changes in Fibrin Clotting and Fibrinolysis.

Amélie I S Sobczak, Fladia A Phoenix, Samantha J Pitt, Ramzi A Ajjan, Alan J Stewart

Open access · hybridAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Total plasma magnesium, zinc, copper and selenium concentrations in obese patients before and after bariatric surgery.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
  5. Review
  6. Antioxidant/anti-inflammatory effect of MgReviews in medical virology · 2022
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Anomalous mechanics of ZnProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Review
  13. Coagulatory Defects in Type-1 and Type-2 Diabetes.International journal of molecular sciences · 2019
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amélie I S SobczakSchool of Medicine, University of St Andrews, St Andrews, United Kingdom.
Fladia A PhoenixLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Samantha J PittSchool of Medicine, University of St Andrews, St Andrews, United Kingdom.
Ramzi A AjjanLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Alan J StewartSchool of Medicine, University of St Andrews, St Andrews, United Kingdom.ORCID 0000-0003-4580-1840
University of St Andrews · GBUniversity of Leeds · GB

Funding

British Heart Foundation FS/15/42/31556British Heart Foundation PG/15/9/31270FS/15/42/3155 British Heart FoundationPG/15/9/31270 British Heart Foundation
6 · The paper itself

Abstract

Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM and 47 age- and sex-matched controls without diabetes. Fibrin clot characteristics were assessed using a validated turbidimetric assay and associations with plasma magnesium concentration were examined. Plasma concentrations of fibrinogen, plasminogen activator inhibitor-1 (PAI-1), and lipids were measured and fibrin fiber diameters assessed using scanning electron microscopy. Fibrin clot maximum absorbance was unchanged in subjects with T1DM compared with controls, while lysis time was prolonged (

Indexed as

Blood CoagulationFibrinolysisAdolescentAdultCase-Control StudiesDiabetes Mellitus, Type 1FemaleFibrinGlycated HemoglobinHomeostasisHumansLipidsLipoproteinsMagnesiumMaleMicroscopy, Electron, ScanningFibrinGlycated Hemoglobinhemoglobin A1c protein, humanLipidsLipoproteinsMagnesiumPlasminogen Activator Inhibitor 1SERPINE1 protein, human

Identifiers

PMID31942750
PMCPMC6997031
OpenAlexW2998196017

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.