ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Longitudinal Association Between Energy Regulation and Fatigability in Mid-to-Late Life.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Mediating pathways of physical capabilities: linking perceived physical fatigability to motoric cognitive risk syndrome in community older adults.BMC geriatrics · 2026Article
- Does sit-to-stand transition velocity vary across the day? Association with physical functioning and fatigability in community-dwelling older adults.Innovation in aging · 2026Article
- Sleep quality and possible sarcopenia in community-dwelling older adults: physical and mental fatigability as mediators.BMC geriatrics · 2025Article
- The association between sensor-based assessments of daily physical activity patterns and physical fitness in older adults: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- Gait Characteristics Related to Fatigue in Patients With Type 2 Diabetes: Cross-Sectional Study.Cureus · 2025Article
- Using Wearable Devices to Examine the Associations of Sedentary Behavior with Perceived and Performance Fatigability Among Older Adults: The Study of Muscle, Mobility and Aging (SOMMA).Sensors (Basel, Switzerland) · 2025Article
- Moderate-to-Vigorous Physical Activity at any Dose Reduces All-Cause Dementia Risk Regardless of Frailty Status.Journal of the American Medical Directors Association · 2025Article
- Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Usual-paced 400 m long distance corridor walk estimates cardiorespiratory fitness among older adults: The Study of Muscle, Mobility and Aging.Journal of the American Geriatrics Society · 2024Article
- Transfemoral limb loss modestly increases the metabolic cost of optimal control simulations of walking.PeerJ · 2024Article
- Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Changes in Objectively Measured Physical Activity Are Associated With Perceived Physical and Mental Fatigability in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Prospective Associations Between Physical Activity and Perceived Fatigability in Older Men: Differences by Activity Type and Baseline Marital Status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Association between walking energy utilisation and longitudinal cognitive performance in older adults.Age and ageing · 2022Article
- Article
- Longitudinal associations between energy utilization and brain volumes in cognitively normal middle aged and older adults.Scientific reports · 2022Article
- Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Association Between Walking Energetics and Fragmented Physical Activity in Mid- to Late-Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Association of Mitochondrial Function, Substrate Utilization, and Anaerobic Metabolism With Age-Related Perceived Fatigability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeficits in energy production and utilization have been linked to higher fatigue and functional decline with aging. Lesser known is whether individuals with a combination of low peak energy capacity and high energy costs for mobility (eg, impaired energy regulation) are more likely to experience the onset and progression of high fatigability with aging.
methodsParticipants in the Baltimore Longitudinal Study of Aging (n = 651, 49.0% male, mean age 71.9, range 50-94) with ≥2 visits who completed fatigability (Borg rating of perceived exertion [RPE] after a 5-minute 1.5 mph treadmill walk), slow walking energy expenditure (VO2 mL/kg/min), and peak walking energy expenditure (VO2 mL/kg/min), testing between 2007 and 2018. The longitudinal association between each measure of energy expenditure, a ratio of energy cost-to-capacity, and perceived fatigability was modeled using mixed effects models adjusted for age, body composition, and comorbidities. Time to higher perceived fatigability (RPE ≥ 10) was modeled using Cox proportional hazards models.
resultsIn continuous analyses, higher slow walking energy expenditure (p < .05) and a higher cost ratio (p ≤ .001) were associated with greater perceived fatigability over time. Cox proportional hazards models using tertiles of the cost ratio suggest that, compared to those in the lowest tertile, those in the middle and highest tertiles had 1.89 (95% confidence interval [CI]: 1.57-5.16) and 2.85 (95% CI: 1.05-3.40) times greater risk of developing higher fatigability, respectively.
conclusionFindings suggest that strategies to prevent fatigability should consider methods to improve energy regulation by targeting both the independent and combined effects of declining peak capacity and rising energy costs for mobility with aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.