ArticleAnimal models and experimental medicine2019
The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device.
Article in Animal models and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 21 citations in OpenAlex.
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- COVID-19 Worsens Chronic Lumbosacral Radicular Pain-Case Series Report.International journal of environmental research and public health · 2022Article
- MERS-CoV infection causes brain damage in human DPP4-transgenic mice through complement-mediated inflammation.The Journal of general virology · 2021Article
- Airborne transmission of respiratory viruses.Science (New York, N.Y.) · 2021Review
- SARS-CoV-2 targets glial cells in human cortical organoids.Stem cell reports · 2021Article
- Transcriptional Landscape of Vero E6 Cells during Early Swine Acute Diarrhea Syndrome Coronavirus Infection.Viruses · 2021Article
- Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?Journal of neuroscience research · 2021Review
- Neuropathology of COVID-19 (neuro-COVID): clinicopathological update.Free neuropathology · 2021Article
- Aerosol Transmission of Coronavirus and Influenza Virus of Animal Origin.Frontiers in veterinary science · 2021Review
- Does SARS-Cov-2 invade the brain? Translational lessons from animal models.European journal of neurology · 2020Review
- The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system.Cytokine & growth factor reviews · 2020Review
- The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device.Animal models and experimental medicine · 2019Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMiddle East respiratory syndrome coronavirus (MERS-CoV), which is not fully understood in regard to certain transmission routes and pathogenesis and lacks specific therapeutics and vaccines, poses a global threat to public health.
methodsTo simulate the clinical aerosol transmission route, hDPP4 transgenic mice were infected with MERS-CoV by an animal nose-only exposure device and compared with instillation-inoculated mice. The challenged mice were observed for 14 consecutive days and necropsied on days 3, 5, 7, and 9 to analyze viral load, histopathology, viral antigen distribution, and cytokines in tissues.
resultsMERS-CoV aerosol-infected mice with an incubation period of 5-7 days showed weight loss on days 7-11, obvious lung lesions on day 7, high viral loads in the lungs on days 3-9 and in the brain on days 7-9, and 60% survival. MERS-CoV instillation-inoculated mice exhibited clinical signs on day 1, obvious lung lesions on days 3-5, continuous weight loss, 0% survival by day 5, and high viral loads in the lungs and brain on days 3-5. Viral antigen and high levels of proinflammatory cytokines and chemokines were detected in the aerosol and instillation groups. Disease, lung lesion, and viral replication progressions were slower in the MERS-CoV aerosol-infected mice than in the MERS-CoV instillation-inoculated mice.
conclusionhDPP4 transgenic mice were successfully infected with MERS-CoV aerosols via an animal nose-only exposure device, and aerosol- and instillation-infected mice simulated the clinical symptoms of moderate diffuse interstitial pneumonia. However, the transgenic mice exposed to aerosol MERS-CoV developed disease and lung pathology progressions that more closely resembled those observed in humans.
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