Evidence map›Paper›PMID 31942528›Full record

ReviewAging medicine (Milton (N.S.W))2019

Osteosarcopenia: A case of geroscience.

Ben Kirk, Ahmed Al Saedi, Gustavo Duque

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging medicine (Milton (N.S.W)), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04730622 (Study of Parameters of Bone Fragility and Sarcopenia in Patients Undergoing Surgery for Fracture of the Femoral Neck), which is not on this map. Cited by 78 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 4 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730622 recruitingnot on this mapstarted 2020, after this paper: background citation

Study of Parameters of Bone Fragility and Sarcopenia in Patients Undergoing Surgery for Fracture of the Femoral Neck

TypeobservationalSponsorIstituto Ortopedico RizzoliRan2020 to 2026Enrolled100ConditionsOsteoporotic Fracture of Femur, Osteoarthritis, HipArmsSARC-F questionnaire, Bone tissue histology, Muscle tissue histology, Myostatin serum levels, Insulin-like growth factor 1 (IGF-1) serum levels
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 4 syntheses or guidelines pooled it, 189 citations in OpenAlex.

  1. Pooled it
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  5. Greater DJBMR plus · 2026
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  11. The effectiveness of bisphosphonates vs denosumab in people with dementia or frailty post hip fracture: a multi-database cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  15. Observational
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ben KirkDepartment of Medicine Western Health Melbourne Medical School University of Melbourne Melbourne Vic. Australia.ORCID https://orcid.org/0000-0002-0176-776X
Ahmed Al SaediDepartment of Medicine Western Health Melbourne Medical School University of Melbourne Melbourne Vic. Australia.ORCID https://orcid.org/0000-0002-2479-5317
Gustavo DuqueDepartment of Medicine Western Health Melbourne Medical School University of Melbourne Melbourne Vic. Australia.ORCID https://orcid.org/0000-0001-8126-0637
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many older persons lose their mobility and independence due to multiple diseases occurring simultaneously. Geroscience is aimed at developing innovative approaches to better identify relationships among the biological processes of aging. Osteoporosis and sarcopenia are two of the most prevalent chronic diseases in older people, with both conditions sharing overlapping risk factors and pathogenesis. When occurring together, these diseases form a geriatric syndrome termed "osteosarcopenia," which increases the risk of frailty, hospitalizations, and death. Findings from basic and clinical sciences aiming to understand osteosarcopenia have provided evidence of this syndrome as a case of geroscience. Genetic, endocrine, and mechanical stimuli, in addition to fat infiltration, sedentarism, and nutritional deficiencies, affect muscle and bone homeostasis to characterize this syndrome. However, research is in its infancy regarding accurate diagnostic markers and effective treatments with dual effects on muscle and bone. To date, resistance exercise remains the most promising strategy to increase muscle and bone mass, while sufficient quantities of protein, vitamin D, calcium, and creatine may preserve these tissues with aging. More recent findings, from rodent models, suggest treating ectopic fat in muscle and bone marrow as a possible avenue to curb osteosarcopenia, although this needs testing in human clinical trials.

Indexed as

bonecross talkgerosciencemuscleosteosarcopenia

Identifiers

PMID31942528
PMCPMC6880711
OpenAlexW2972371635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.