ArticleAging medicine (Milton (N.S.W))2019
Associations between a laboratory frailty index and adverse health outcomes across age and sex.
Article in Aging medicine (Milton (N.S.W)), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The frailty index based on laboratory test data as a tool to investigate the impact of frailty on health outcomes: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Evaluation of the FI-Lab, a laboratory-based, automated frailty index for acute care: A multicohort study.PLoS medicine · 2026Article
- Frailty status and mortality among patients with cardiometabolic diseases in an international multi-cohort study.iScience · 2026Article
- Heart Stress, Frailty and Mortality Risk in two prospective cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice.GeroScience · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- FI-Lab predicts all-cause mortality, but not successful rehabilitation, among patients aged 65 and older after hip or pelvic fracture.Frontiers in medicine · 2025Article
- Association between frailty index based on laboratory tests and all-cause mortality in critically ill patients with heart failure.ESC heart failure · 2024Observational
- Article
- Low HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) Score Increases the Risk of Post-Stroke Cognitive Impairment: A Multicenter Cohort Study.Clinical interventions in aging · 2024Article
- Machine learning analyses identify multi-modal frailty factors that selectively discriminate four cohorts in the Alzheimer's disease spectrum: a COMPASS-ND study.BMC geriatrics · 2023Article
- How to construct a frailty index from an existing dataset in 10 steps.Age and ageing · 2023Article
- Comprehensive Geriatric Care in Older Adults: Walking Ability after an Acute Fracture.Medical sciences (Basel, Switzerland) · 2023Article
- A novel easy-to-use index to predict institutionalization and death in older population - a 10-year population-based follow-up study.BMC geriatrics · 2023Article
- The impact of cardiovascular health and frailty on mortality for males and females across the life course.BMC medicine · 2022Article
- Unsupervised learning of aging principles from longitudinal data.Nature communications · 2022Article
- Frailty indices based on self-report, blood-based biomarkers and examination-based data in the Canadian Longitudinal Study on Aging.Age and ageing · 2022Article
- Frailty index based on laboratory tests improves prediction of short-and long-term mortality in patients with critical acute myocardial infarction.Frontiers in medicine · 2022Article
- A Simple Risk Score Based on Routine Clinical Parameters Can Predict Frailty in Hospitalized Heart Failure Patients.Journal of clinical medicine · 2021Article
- Number of teeth is associated with all-cause and disease-specific mortality.BMC oral health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEarly frailty may be captured by a frailty index (FI) based entirely on vital signs and laboratory tests. Our aim was to examine associations between a laboratory-based FI (FI-Lab) and adverse health outcomes, and investigate how this changed with age.
methodsUp to 8988 individuals aged 20+ years from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey cohorts were included. Characteristics of the FI-Lab were compared to those of a self-reported clinical FI. Associations between each FI and health care use, self-reported health, and disability were examined in the full sample and across age groups.
resultsLaboratory-based FI scores increased with age but did not demonstrate expected sex differences. Women aged 20-39 years had higher FI scores than men; this pattern reversed after age 60 years. FI-Lab scores were associated with poor self-reported health (odds ratio[95% confidence interval]: 1.46[1.39-1.54]), high health care use (1.35[1.29-1.42]), and high disability (1.41[1.32-1.50]), even among those aged 20-39 years.
conclusionHigher FI-Lab scores were associated with poor health outcomes at all ages. Associations in the youngest group support the notion that deficit accumulation occurs across the lifespan. FI-Lab scores could be utilized as an early screening tool to identify deficit accumulation at the cellular and molecular level before they become clinically visible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.