ArticleAging medicine (Milton (N.S.W))2018
Reliability of the MRI-based Brain Atrophy and Lesion Index in the evaluation of whole-brain structural health.
Article in Aging medicine (Milton (N.S.W)), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Age-Related Whole-Brain Structural Changes in Relation to Cardiovascular Risks Across the Adult Age Spectrum.Frontiers in aging neuroscience · 2019Article
- Reliability of the MRI-based Brain Atrophy and Lesion Index in the evaluation of whole-brain structural health.Aging medicine (Milton (N.S.W)) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Brain Atrophy and Lesion Index (BALI), which evaluates several common aging-related MRI changes in combination, has been validated as a feasible method to assess the status of structural brain health. Previous studies have been based primarily on older participants and high-field MRI. Here, we tested the generalizability of the BALI by examining its measurement properties in a wide age range at both high and conventional MRI field strengths.
methodsSubjects (n = 229) who had T2WI at either 1.5T or 3.0T were grouped into younger (age ≤ 60 years) and older (age > 60 years) groups. Image evaluation and scoring were performed independently by two experienced neuroradiologists who have mastered the BALI method. Inter- and intrarater agreement rates were examined comparing age groups and field strengths.
resultsThe intraclass correlation coefficient for the BALI total score was consistently high under each experimental condition (interrater ICC ≥ 0.92, 95% CI: 0.84-0.96), with no statistical difference between age groups (Fisher
conclusionThe BALI based on T2WI can be reliably applied to the evaluation of the whole-brain health of both younger and older adults at both field strengths, even though high-field MRI is preferable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.