Evidence map›Paper›PMID 31942442›Full record

ArticleBladder cancer (Amsterdam, Netherlands)2019

Alexandra K Walker, Juri Na, Lisa Browning, Nada Humayun-Zakaria, Maurice P Zeegers, K K Cheng, Nicholas D James, Richard T Bryan, Roland Arnold, Anne E Kiltie

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bladder cancer (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Alexandra K WalkerCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
Juri NaCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
Lisa BrowningDepartment of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, and NIHR Oxford Biomedical Research Centre, Oxford, UK.
Nada Humayun-ZakariaThe Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Maurice P ZeegersNUTRIM School for Nutrition and Translational Research in Metabolism and CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.
K K ChengThe Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Nicholas D JamesThe Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Richard T BryanThe Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Roland ArnoldThe Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Anne E KiltieCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
University of Birmingham · GBUniversity of Oxford · GBJohn Radcliffe Hospital · GBMaastricht University · NL

Funding

Cancer Research UK 23279
6 · The paper itself

Abstract

backgroundDNA double strand breaks are the cytotoxic lesions produced by ionising radiation. Critical for the repair of these lesions is the DNA damage response protein MRE11 which, in a complex with RAD50 and NBS1, mediates DNA damage signalling and double-strand break repair. We previously found the presence of an

objectivesTo look for further evidence in support of the SNP/isoform association in a larger panel of germline and tumour samples donated by patients diagnosed with invasive bladder cancer, and to test the hypothesis that bladder cancer cells expressing

methodsGermline DNA from 189 patients with invasive bladder cancer (141 T2, 48 T1) was genotyped for the rs1805363

resultsOf the 189 germline DNA samples, 22 contained both the A minor allele and G major allele with the remaining wild type containing only the G major allele. LOH was identified in seven of 17 available tumour samples. Tumour

conclusionsIn this study the

Indexed as

Bladder cancerMRE11MRE11 isoform 1MRE11 isoform 2rs1805363

Identifiers

PMID31942442
PMCPMC6949534
OpenAlexW2962051519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.