Evidence map›Paper›PMID 31942412›Full record

ArticleBalkan journal of medical genetics : BJMG2019

Results of Liquid Biopsy Studies by Next Generation Sequencing in Patients with Advanced Stage Non-small Cell Lung Cancer: Single Center Experience from Turkey.

M Buyuksimsek, M Togun, Kara I Oguz, A Bisgin, I Boga, M Tohumcuoglu, A Ogul, Yetisir A Evren, B Sahin, Sumbul H Erdem and 1 more

Open access · goldAbstract read
In one paragraph

Article in Balkan journal of medical genetics : BJMG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

M BuyuksimsekDepartment of Medical Oncology, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
M TogunDepartment of Internal Medicine, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
Kara I OguzDepartment of Medical Oncology, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
A BisginMedical Genetics Department of Balcali Hospital and Clinics and University Faculty of Medicine, Adana, Turkey.
I BogaÇukurova University AGENTEM (Adana Genetic Diseases Diagnosis and Treatment Center), Adana, Turkey.
M TohumcuogluDepartment of Medical Oncology, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
A OgulDepartment of Medical Oncology, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
Yetisir A EvrenDepartment of Medical Oncology, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
B SahinDepartment of Medical Oncology, Çukurova University Faculty of Medicine, Balcali Clinics and Hospital, Adana, Turkey.
Sumbul H ErdemDepartment of Internal Medicine, University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey.
C MiriliDepartment of Medical Oncology Ataturk University Faculty of Medicine, Erzurum, Turkey.
Cukurova University · TRAtatürk University · TRSağlık Bilimleri Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies demonstrated the utility of plasma-based cell-free circulating tumor DNA (ccfDNA) in determination of mutations in non-small cell lung cancer (NSCLC). We aimed to report our results of next generation sequencing (NGS) using liquid biopsy in patients with NSCLC. Patients with advanced stage NSCLC were enrolled and their genomic profiling results were recorded. Next generation sequencing targeted panel includes 19 hot-spot genes. The plasma was separated from the peripheral blood sample and ccfDNAs were isolated for NGS. We performed genomic profiling in 100 patients (20 females and 80 males) with a median age of 59.3 (range 26-79). A second liquid biopsy was performed in eight patients who developed progressive disease after the first treatment. The study population had adenocarcinoma (AC) (

Indexed as

Liquid biopsyNew generation sequencing (NGS)Non-small cell lung cancer (NSCLC)

Identifiers

PMID31942412
PMCPMC6956641
OpenAlexW2997636417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.