ArticleJournal of Cancer2020
The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population.
Article in Journal of Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- LDCT combined with serum miR-4638-3p expression enhances NSCLC diagnostic efficacy and rs6601178 polymorphism susceptibility association.Journal of cardiothoracic surgery · 2026Article
- Abnormal methylation of HOXA11 promoter promotes tumor progression in testicular germ cell tumor.American journal of translational research · 2024Article
- The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision.Non-coding RNA · 2023Review
- Article
- Long noncoding HOXA11-AS knockdown suppresses the progression of non-small cell lung cancer by regulating miR-3619-5p/SALL4 axis.Journal of molecular histology · 2021Article
- Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (LncRNA) have been wildly explored in several malignant tumors. This study aimed to evaluate the effect of HOXA11-AS polymorphisms (rs17427875 and rs11564004) on lung cancer susceptibility and its interaction with smoking exposure. This hospital-based case-control study, which included 466 cases and 557 controls, was carried out in Shenyang City, Liaoning province. The genotyping method was TaqMan allelic discrimination assay and all statistical analysis were performed by SPSS 20.0 and R (3.5.3). The results demonstrated that HOXA11AS-rs17427875 polymorphisms were correlated with the susceptibility of lung adenocarcinoma. T alleles of rs17427875 played a portal role in increasing lung adenocarcinoma risk. HOXA11AS-rs11564004 polymorphisms had the significant association with lung cancer risks, as well as its subtypes like non-small cell lung cancer, adenocarcinoma. The allele G of rs11564004 acted as a protective factor for lung cancer. The similar results were observed in the homozygous model and recessive model of rs11564004. Nevertheless, interaction analysis of the additive and multiplicative model scales showed no statistical significance between HOXA11-AS polymorphisms and smoking exposure in the development of lung cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.