Evidence map›Paper›PMID 31942017›Full record

ArticleScientific reports2020

Feasibility Study of MRI Muscles Molecular Imaging in Evaluation of Early Post-Mortem Interval.

Daniela Sapienza, Alessio Asmundo, Salvatore Silipigni, Ugo Barbaro, Antonella Cinquegrani, Francesca Granata, Valeria Barresi, Patrizia Gualniera, Antonio Bottari, Michele Gaeta

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. European radiology experimental · 2025
    Article
  3. Article
  4. RedefiningFrontiers in microbiology · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Daniela SapienzaDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Legal Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. daniela.sapienza@unime.it.ORCID http://orcid.org/0000-0002-3595-7086
Alessio AsmundoDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Legal Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.
Salvatore SilipigniDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Radiological Sciences, University of Messina, Messina, Italy.
Ugo BarbaroDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Radiological Sciences, University of Messina, Messina, Italy.
Antonella CinquegraniDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Radiological Sciences, University of Messina, Messina, Italy.
Francesca GranataDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Radiological Sciences, University of Messina, Messina, Italy.
Valeria BarresiDepartment of Human Pathology in Adulthood and Evolutive Age, University of Messina, Messina, Italy.
Patrizia GualnieraDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Legal Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.
Antonio BottariDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Radiological Sciences, University of Messina, Messina, Italy.
Michele GaetaDepartment of Biomedical and Dental Sciences,and of Morphological and Functional Images, Section of Radiological Sciences, University of Messina, Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estimating early postmortem interval (EPI) is a difficult task in daily forensic activity due to limitations of accurate and reliable methods. The aim of the present work is to describe a novel approach in the estimation of EPI based on quantitative magnetic resonance molecular imaging (qMRMI) using a pig phantom since post-mortem degradation of pig meat is similar to that of human muscles. On a pig phantom maintained at 20° degree, using a 1.5 T MRI scanner we performed 10 scans (every 4 hours) monitoring apparent diffusion coefficient (ADC), fractional anisotropy (FA) magnetization transfer ration (MTR), tractography and susceptibility weighted changes in muscles until 36 hours after death. Cooling of the phantom during the experiment was recorded. Histology was also obtained. Pearson's Test was carried out for time correlation between post-mortem interval and MRI data. We found a significative inverse correlation between ADC, FA, MT values and PMI. Our preliminary data shows that post-mortem qMRMI is a potential powerful tool in accurately determining EPI and is worth of further investigation.

Indexed as

Phantoms, ImagingPostmortem ChangesAnimalsFeasibility StudiesMagnetic Resonance ImagingMeatMolecular ImagingMuscle, SkeletalSwine

Identifiers

PMID31942017
PMCPMC6962370
OpenAlexW3000098617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.