ArticleNature communications2020
Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Anti-infective compounds forSustainable microbiology · 2026Review
- Retracing the path of evolution: polymorphisms ofEmerging microbes & infections · 2025Article
- Plagued by the Past, Pressed by the Present: A One Health Perspective onBiomedicines · 2025Review
- Hotspots of genetic change in Yersinia pestis.Nature communications · 2025Article
- Pathogenicity and virulence ofVirulence · 2024Review
- Detection of prions from spiked and free-ranging carnivore feces.Scientific reports · 2024Article
- Tad pili contribute to the virulence and biofilm formation of virulentFrontiers in cellular and infection microbiology · 2024Article
- Strategies and materials for the prevention and treatment of biofilms.Materials today. Bio · 2023Review
- Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics.Communications biology · 2023Article
- The complex genomic diversity ofEcology and evolution · 2023Article
- The whole-cell proteome shows the characteristics of macrolides-resistant Bordetella pertussis in China linked to the biofilm formation.Archives of microbiology · 2023Article
- The role of reservoir species in mediating plague's dynamic response to climate.Royal Society open science · 2023Article
- Article
- Article
- Polygenic plague resistance in the great gerbil uncovered by population sequencing.PNAS nexus · 2022Article
- Small Insertions and Deletions Drive Genomic Plasticity during Adaptive Evolution of Yersinia pestis.Microbiology spectrum · 2022Review
- Article
- Proteogenomic discovery of sORF-encoded peptides associated with bacterial virulence in Yersinia pestis.Communications biology · 2021Article
- Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis.Gastroenterology · 2021Article
- Assessing the origins of the European Plagues following the Black Death: A synthesis of genomic, historical, and ecological information.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yersinia pestis is transmitted from fleas to rodents when the bacterium develops an extensive biofilm in the foregut of a flea, starving it into a feeding frenzy, or, alternatively, during a brief period directly after feeding on a bacteremic host. These two transmission modes are in a trade-off regulated by the amount of biofilm produced by the bacterium. Here by investigating 446 global isolated Y. pestis genomes, including 78 newly sequenced isolates sampled over 40 years from a plague focus in China, we provide evidence for strong selection pressures on the RNA polymerase ω-subunit encoding gene rpoZ. We demonstrate that rpoZ variants have an increased rate of biofilm production in vitro, and that they evolve in the ecosystem during colder and drier periods. Our results support the notion that the bacterium is constantly adapting-through extended phenotype changes in the fleas-in response to climate-driven changes in the niche.
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