ReviewJCI insight2020
Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary.
Review in JCI insight, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Understanding Participants' and Health Professionals' Perceptions and Experiences of Time-Restricted Eating: A Systematic Review of Qualitative Evidence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review.Journal of neuro-oncology · 2023Pooled it
- Association between periodontal disease and non-apnea sleep disorder: a systematic review.Clinical oral investigations · 2020Pooled it
- Effect of Continuous Perioperative Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomized Controlled Trial.Clinical interventions in aging · 2026Trial
- Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain.The Journal of clinical investigation · 2025Trial
- A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS).Human vaccines & immunotherapeutics · 2024Trial
- Early postoperative ward-level circadian-disruptive exposures and short- and long-term outcomes after gastrointestinal cancer surgery: a prospective cohort study.Surgical endoscopy · 2026Article
- Ancestry Matters in Decoding Immunity.Immunology and cell biology · 2026Article
- Review
- Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep.Brain, behavior, & immunity - health · 2026Article
- Short- and Long-Term Chrono-Immune Consequences of Dim Light at Night Exposure in Male Mice at Different Life Stages.Clocks & sleep · 2026Article
- Circadian Phase Modulates Embryonic Susceptibility to Bisphenol A-Induced ASD-Related Behavioral Alterations viaToxics · 2026Article
- Spatial transcriptomics and single-nucleus RNA sequencing reveal rAAV2- and rAAV9-specific transduction signatures in the mouse liver.Gene therapy · 2026Article
- Exploring sleep health and circadian rhythm disruption in Sjögren's disease: an accelerometric and self-reported cross-sectional study.Rheumatology (Oxford, England) · 2026Article
- Sleep Disturbances and Non-REM Phase Alterations in Children with Celiac Disease: A Combined Questionnaire and EEG Study.Brain sciences · 2026Article
- Reference Intervals for Lymphocyte Subpopulations in Healthy Chinese Han Adults: A Single-Center Study.Journal of clinical laboratory analysis · 2026Article
- The kynurenine pathway in depression and schizophrenia: convergent signals, divergent states, and clinical signatures.EXCLI journal · 2026Review
- Associations of viral infections, including cutaneous warts, and sleep quality with immune function in treatment-naïve breast cancer patient: a cross-sectional study.Frontiers in medicine · 2026Article
- Article
- Circadian-immune crosstalk in insomnia disorder: mechanisms and therapeutic implications.Frontiers in neuroscience · 2026Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.